Dr Md Rezaul Karim, Registrar (Neurology), Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail:
Mymensingh Med J. 2021 Apr;30(2):301-306.
Migraine is one of the most disabling types of headache. It affects 4-6% of men and 13-18% of women; more than 80% of them are under 30 years. Many theories to explain mechanism of migraine are present; role of serum magnesium is one of them. This Cross-sectional analytical study was designed to see serum magnesium level status of migraine patients in Bangladesh and to find out any relation. The study was carried out in Outpatient Department of Neurology of Mymensingh Medical College Hospital, Mymensingh, Bangladesh from July 2017 to September 2018. Seventy (70) patients between 18-60 years of both sexes with headache fulfilling the criteria for migraine were enrolled as migraine group. Patients with headache who did not fulfill the criteria of migraine enrolled as non migraine group. Patients were included in both groups after exclusion of structural lesions, magnesium containing drug intake, pregnancy, menstruation, alcoholism, renal or GIT problems. Serum magnesium levels were studied in both groups and compared with each other. All related factors such as age, sex, family history of migraine, occupation were assessed. Fifty one (51) of 70 patients (72.85%) was female and 19(27.15%) were male in migraine group. Thirty eight (54.28%) of cases were between 18 and 30 years old. Thirty nine (55.71%) of migraine patients had history of similar headache in their family. Severe headache in 51.43% of migraine patients and 30% had more than three attacks per month. Mean serum magnesium level was 1.70 mg/dl in migraine group and 1.85 mg/dl in non migraine group (p=0.001). Serum magnesium level was also lower in severe migraine headache in comparison to mild to moderate headache (p=0.01). No significant difference was found in serum magnesium level compared according to age, sex, frequency of attack and presence or absence of aura. The study concludes that serum magnesium in migraine patients was significantly lower than non migraine group. It was also lower in migraine patient having severe headache in comparison with mild to moderate headache, though in both conditions they were within normal range.
偏头痛是最常见的头痛类型之一。它影响 4-6%的男性和 13-18%的女性；其中超过 80%的人年龄在 30 岁以下。目前有许多解释偏头痛发病机制的理论，其中包括血清镁的作用。本横断面分析性研究旨在观察孟加拉国偏头痛患者的血清镁水平状况并找出任何关系。该研究于 2017 年 7 月至 2018 年 9 月在孟加拉国迈门辛医学院医院神经内科门诊进行。70 名年龄在 18-60 岁之间的男女偏头痛患者符合偏头痛标准，被纳入偏头痛组。不符合偏头痛标准的头痛患者被纳入非偏头痛组。排除结构病变、含镁药物摄入、妊娠、月经、酗酒、肾或胃肠道问题后，将这些患者纳入两组。研究了两组患者的血清镁水平并进行了比较。评估了所有相关因素，如年龄、性别、偏头痛家族史、职业。偏头痛组 70 例患者中 51 例（72.85%）为女性，19 例（27.15%）为男性。38 例（54.28%）患者年龄在 18-30 岁之间。39 例（55.71%）偏头痛患者有家族类似头痛史。51.43%的偏头痛患者头痛剧烈，30%的患者每月发作超过 3 次。偏头痛组平均血清镁水平为 1.70mg/dl，非偏头痛组为 1.85mg/dl（p=0.001）。与轻至中度头痛相比，严重偏头痛头痛患者的血清镁水平较低（p=0.01）。根据年龄、性别、发作频率以及有无先兆，血清镁水平无显著差异。研究结论是，偏头痛患者的血清镁水平明显低于非偏头痛组。与轻至中度头痛相比，偏头痛患者的头痛严重程度也较低，尽管在这两种情况下，镁水平均在正常范围内。
