Abucar Elias A M, Kern Mascha, Kurth Tobias, Meierkord Anne, Gertler Maximilian, Seybold Joachim, Theuring Stefanie, Mockenhaupt Frank P
Institute of International Health, Charité Center for Global Health, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Institute of Public Health, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Epidemiol Infect. 2025 Mar 31;153:e60. doi: 10.1017/S0950268825000366.
Health-related quality of life (HRQoL) in the context of COVID-19 is not fully understood. We assessed HRQoL using Patient-Reported Outcomes Measurement Information System® measures among 559 former COVID-19 patients and 298 non-infected individuals. HRQoL was captured once up to 2 years after the initial test. Additionally, we described associations of characteristics with impaired HRQoL. Overall, HRQoL scores were inferior among former patients. A meaningful group difference of at least three T-score points was discernible until 12 months after testing for fatigue (3.1), sleep disturbance (3.5), and dyspnoea (3.7). Cognitive function demonstrated such difference even at >18 months post-infection (3.3). Following dichotomization, pronounced differences in impaired HRQoL were observed in physical (19.2% of former patients, 7.3% of non-infected) and cognitive function (37.6% of former patients, 16.5% of non-infected). Domains most commonly affected among former patients were depression (34.9%), fatigue (37.4%), and cognitive function. Factors that associated with HRQoL impairments among former patients included age (OR ≤2.1), lower education (OR ≤5.3), and COVID-19-related hospitalization (OR ≤4.7), among others. These data underline the need for continued attention of the scientific community to further investigate potential long-term health limitations after COVID-19 to ultimately establish adequate screening and management options for those affected.
新冠疫情背景下的健康相关生活质量（HRQoL）尚未得到充分理解。我们使用患者报告结局测量信息系统（Patient-Reported Outcomes Measurement Information System®）量表对559名新冠康复患者和298名未感染个体的健康相关生活质量进行了评估。在初次检测后的两年内对健康相关生活质量进行了一次评估。此外，我们描述了各种特征与健康相关生活质量受损之间的关联。总体而言，新冠康复患者的健康相关生活质量得分较低。在检测疲劳（3.1）、睡眠障碍（3.5）和呼吸困难（3.7）后的12个月内，前患者组与非感染组之间存在至少3个T分的显著差异。即使在感染18个月后，认知功能也存在这种差异（3.3）。二分法分析后，在身体（19.2%的前患者，7.3%的非感染个体）和认知功能（37.6%的前患者，16.5%的非感染个体）方面，健康相关生活质量受损存在显著差异。前患者中最常受影响的领域是抑郁（34.9%）、疲劳（37.4%）和认知功能。与新冠康复患者健康相关生活质量受损相关的因素包括年龄（比值比≤2.1）、教育程度较低（比值比≤5.3）以及与新冠相关的住院治疗（比值比≤4.7）等。这些数据强调了科学界需要持续关注，以进一步研究新冠疫情后潜在的长期健康限制，最终为受影响者建立适当的筛查和管理方案。
