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关于与子痫前期、原发性高血压和胎儿宫内生长受限相关的人类胎盘的定量结构研究。

Quantitative structural studies on human placentas associated with pre-eclampsia, essential hypertension and intrauterine growth retardation.

作者信息

Boyd P A, Scott A

出版信息

Br J Obstet Gynaecol. 1985 Jul;92(7):714-21. doi: 10.1111/j.1471-0528.1985.tb01454.x.

DOI:10.1111/j.1471-0528.1985.tb01454.x
PMID:4016032
Abstract

Placentas from pregnancies complicated by pre-eclampsia, essential hypertension, hypertension complicated by pre-eclampsia and from normotensive pregnancies resulting in the birth of a singleton small-for-dates (SFD) infant have been studied by quantitative morphometry. The findings have been compared with those from placentas of uncomplicated pregnancies. The placentas from pregnancies complicated by pre-eclampsia and those resulting in a SFD baby had a significantly lower total volume, volume of parenchyma and villous surface area when compared with normal pregnancies of comparable gestation. They also had an increase in areas of multiple infarction and in the volume proportions occupied by fetal capillaries. The placentas from women with essential hypertension uncomplicated by pre-eclampsia were as large as those from normal pregnancies and the villous surface areas were as high. Villous surface area measurements in the different groups were related to gestation and to fetal weight.

摘要

通过定量形态学研究了患有子痫前期、原发性高血压、合并子痫前期的高血压以及导致单胎小于胎龄(SFD)婴儿出生的血压正常的孕妇的胎盘。研究结果与未合并并发症的孕妇胎盘的结果进行了比较。与具有相似孕周的正常妊娠相比,患有子痫前期的孕妇胎盘以及导致SFD婴儿出生的胎盘的总体积、实质体积和绒毛表面积显著降低。它们的多发性梗死面积和胎儿毛细血管所占体积比例也有所增加。未合并子痫前期的原发性高血压女性的胎盘与正常妊娠的胎盘一样大,绒毛表面积也一样高。不同组的绒毛表面积测量值与孕周和胎儿体重有关。

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