McConnell Chelsey, Thoene Melissa, Van Ormer Matthew, Furtado Jeremy D, Korade Zeljka, Genaro-Mattos Thiago C, Hanson Corrine, Anderson-Berry Ann
Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.
Antioxidants (Basel). 2021 Sep 2;10(9):1409. doi: 10.3390/antiox10091409.
Carotenoids are antioxidant nutrients with the potential to provide protection against oxidative stress. Plasma carotenoid concentrations are lower in newborn infants compared to their mothers; however, limited information is available regarding how concentrations differ by gestational age. The objective of this research is to assess maternal and umbilical cord plasma carotenoid concentrations and maternal-umbilical cord plasma ratios across five groups of birth gestational age. Mother-infant dyads were enrolled at delivery for collection of maternal and umbilical cord blood. Plasma carotenoids were analyzed by HPLC and LC-MS/MS. Birth gestational age was categorized into five groups, and the Kruskal-Wallis test compared carotenoid concentrations and maternal-umbilical cord plasma ratios between these groups. A -value of < 0.05 was considered statistically significant. 370 mother-infant dyads were included, with most infants delivered at early term (20.3%) or term (64.6%). Though maternal plasma concentrations increased with birth gestational age, we observed less variability in umbilical cord plasma concentrations, thus the maternal-umbilical cord plasma ratio also increased with birth CGA groups for lutein + zeaxanthin ( = 0.008), β-cryptoxanthin ( = 0.027), α-carotene ( = 0.030); β-carotene approached significance ( = 0.056). Additional research is needed to determine if carotenoid concentrations were physiologic to varying gestational ages or if they were impacted by factors associated with preterm birth.
类胡萝卜素是具有抗氧化作用的营养素，有可能提供针对氧化应激的保护作用。与母亲相比，新生儿的血浆类胡萝卜素浓度较低；然而，关于其浓度如何随胎龄变化的信息有限。本研究的目的是评估五组出生胎龄的母亲和脐带血血浆类胡萝卜素浓度以及母-脐带血血浆比值。母婴对在分娩时登记入组，以采集母亲和脐带血。血浆类胡萝卜素通过高效液相色谱法（HPLC）和液相色谱-串联质谱法（LC-MS/MS）进行分析。出生胎龄分为五组，采用Kruskal-Wallis检验比较这些组之间的类胡萝卜素浓度和母-脐带血血浆比值。P值<0.05被认为具有统计学意义。共纳入370对母婴对，大多数婴儿为早期足月（20.3%）或足月（64.6%）分娩。尽管母亲血浆浓度随出生胎龄增加，但我们观察到脐带血血浆浓度的变异性较小，因此母-脐带血血浆比值也随出生胎龄增加，叶黄素+玉米黄质（P = 0.008）、β-隐黄质（P = 0.027）、α-胡萝卜素（P = 0.030）；β-胡萝卜素接近显著性（P = 0.056）。需要进一步研究以确定类胡萝卜素浓度对于不同胎龄是否具有生理学意义，或者它们是否受到与早产相关因素的影响。
