Robust multi-outcome regression with correlated covariate blocks using fused LAD-lasso.

Lasso is a popular and efficient approach to simultaneous estimation and variable selection in high-dimensional regression models. In this paper, a robust fused LAD-lasso method for multiple outcomes is presented that addresses the challenges of non-normal outcome distributions and outlying observations. Measured covariate data from space or time, or spectral bands or genomic positions often have natural correlation structure arising from measuring distance between the covariates. The proposed multi-outcome approach includes handling of such covariate blocks by a group fusion penalty, which encourages similarity between neighboring regression coefficient vectors by penalizing their differences, for example, in sequential data situation. Properties of the proposed approach are illustrated by extensive simulations using BIC-type criteria for model selection. The method is also applied to a real-life skewed data on retirement behavior with longitudinal heteroscedastic explanatory variables.