Kutvonen Olli, Himanen Sari-Leena, Mäkelä Katri
Department of Clinical Neurophysiology, Tampere University Hospital, Tampere, Finland.
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Clin Neurophysiol Pract. 2025 Mar 5;10:95-103. doi: 10.1016/j.cnp.2025.02.007. eCollection 2025.
To assess the capability of shear wave elastography (SWE) to detect muscle denervation.
36 patients underwent electrodiagnostic studies (EDX) of the lower limbs and volunteered to undergo ultrasound examination of the Tibialis anterior (TA) and the Gastrocnemius medialis (GCM) muscles. A variable reflecting the level of anisotropy was created by calculating the difference between the longitudinal and transverse shear wave velocity (SWE-D).
In the TA muscles, SWE-D correlated negatively with the quantity of fibrillation potentials (FP) and the degree of interference pattern (IP) reduction (p = 0.032, r = -0.185 and p = 0.006, r = -0.236, respectively). In the GCM muscles, SWE-D only correlated with the amount of IP reduction among patients of normal weight (p = 0.030, r = -0.285). There was also a significant difference in the overall SWE-D values in the GCM muscles between patients of normal weight and obese patients (p = 0.007).
Loss of anisotropy caused by denervation of muscle tissue may be measured quantitatively by calculating the differences between longitudinal and transverse shear wave velocities. However, obesity seems to hinder the SWE-based assessment of muscle denervation.
Being able to measure anisotropy caused by denervation acts as a base for further development of SWE methods to evaluate neurogenic injury.
评估剪切波弹性成像（SWE）检测肌肉去神经支配的能力。
36例患者接受了下肢电诊断研究（EDX），并自愿接受胫骨前肌（TA）和腓肠肌内侧头（GCM）的超声检查。通过计算纵向和横向剪切波速度之间的差异来创建一个反映各向异性水平的变量（SWE-D）。
在TA肌肉中，SWE-D与纤颤电位（FP）数量和干扰相（IP）减少程度呈负相关（分别为p = 0.032，r = -0.185和p = 0.006，r = -0.236）。在GCM肌肉中，SWE-D仅与正常体重患者的IP减少量相关（p = 0.030，r = -0.285）。正常体重患者和肥胖患者的GCM肌肉总体SWE-D值也存在显著差异（p = 0.007）。
肌肉组织去神经支配导致的各向异性丧失可通过计算纵向和横向剪切波速度之间的差异进行定量测量。然而，肥胖似乎会阻碍基于SWE的肌肉去神经支配评估。
能够测量去神经支配引起的各向异性为进一步开发评估神经源性损伤的SWE方法奠定了基础。
