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丹参多糖的结构表征与药理活性研究进展。

Advances in the structural characterization and pharmacological activity of Salvia miltiorrhiza polysaccharides.

作者信息

Yang Ke, Liu Yi-Jun, Zhang Jia-Ning, Chen Ya-Jing, Yang Jian, Xiao Jun-Ping, Lin Han-Bin, Yang Hong-Jun

机构信息

Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Science, China Jiliang University, Hangzhou, China.

Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.

出版信息

Front Chem. 2025 Mar 14;13:1492533. doi: 10.3389/fchem.2025.1492533. eCollection 2025.

DOI:10.3389/fchem.2025.1492533
PMID:40161004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11949878/
Abstract

BACKGROUND

Bunge is the dried root and rhizome of Bunge, a labiatae plant. polysaccharide (SMP) is the main active component of Bunge. The extraction methods of SMP mainly include water extraction, ultrasonic extraction, enzyme extraction, microwave-assisted extraction and acid-base extraction. It is mainly composed of glucose, arabinose, rhamnose, galactose and other monosaccharides. SMP has a variety of biological activities, including immune regulation, anti-tum, anti-oxidation, myocardial protection, liver protection and so on.

PURPOSE

polysaccharide is widely used in nutraceuticals and pharmaceuticals, and has high research value. Natural polysaccharides are non-toxic, soluble in water, and have a wide range of biological activities, so they have broad research prospects.

METHODS

The data was collected using different online resources including PubMed, Google Scholar, and Web of Science using keywords given below.

RESULTS

In the past decades, various reports have shown that the pharmacological activities of polysaccharides have good effects, and the side effects are small.

CONCLUSION

This paper summarizes the extraction and purification methods, molecular weight, monosaccharide composition, glycosidic linkage, pharmacological activity, toxicity, product development, clinical research and other contents of polysaccharides in recent years, providing a theoretical basis for further study of polysaccharides.

摘要

背景

邦盖是唇形科植物邦盖的干燥根及根茎。多糖（SMP）是邦盖的主要活性成分。SMP的提取方法主要包括水提取、超声提取、酶提取、微波辅助提取和酸碱提取。它主要由葡萄糖、阿拉伯糖、鼠李糖、半乳糖等单糖组成。SMP具有多种生物活性，包括免疫调节、抗肿瘤、抗氧化、心肌保护、肝脏保护等。

目的

多糖在营养保健品和药品中广泛应用，具有很高的研究价值。天然多糖无毒、可溶于水，且具有广泛的生物活性，因此具有广阔的研究前景。

方法

使用包括PubMed、谷歌学术和科学网在内的不同在线资源，通过以下给出的关键词收集数据。

结果

在过去几十年中，各种报告表明多糖的药理活性效果良好，且副作用小。

结论

本文总结了近年来多糖的提取纯化方法、分子量、单糖组成、糖苷键、药理活性、毒性、产品开发、临床研究等内容，为进一步研究多糖提供理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/9ccb839a2ca3/fchem-13-1492533-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/47deaa312d4b/fchem-13-1492533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/da129d7decb5/fchem-13-1492533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/3922fd158458/fchem-13-1492533-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/e33e3dc66fbd/fchem-13-1492533-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/3f057bc03eb9/fchem-13-1492533-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/418a96a87fa5/fchem-13-1492533-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/9ccb839a2ca3/fchem-13-1492533-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/47deaa312d4b/fchem-13-1492533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/da129d7decb5/fchem-13-1492533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/3922fd158458/fchem-13-1492533-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/e33e3dc66fbd/fchem-13-1492533-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/3f057bc03eb9/fchem-13-1492533-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/418a96a87fa5/fchem-13-1492533-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/224d/11949878/9ccb839a2ca3/fchem-13-1492533-g007.jpg

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A Novel Polysaccharide From and Its Protective Effect Against Myocardial Injury.一种源自[具体来源未给出]的新型多糖及其对心肌损伤的保护作用。
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Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways.
丹参多糖通过调节药物和氨基酸代谢信号通路缓解氟苯尼考诱导的雏鸡肝脏代谢紊乱。
Poult Sci. 2022 Sep;101(9):101989. doi: 10.1016/j.psj.2022.101989. Epub 2022 Jun 2.
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Salvia miltiorrhiza polysaccharides ameliorates Staphylococcus aureus-induced mastitis in rats by inhibiting activation of the NF-κB and MAPK signaling pathways.丹参多糖通过抑制 NF-κB 和 MAPK 信号通路的激活来改善金黄色葡萄球菌诱导的大鼠乳腺炎。
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