Ali Elsiddig Ahmed Elsiddig, Muharib R Alruwaili Khalid, Alruwaili Abdulelah H, Talal M Alruwaili Abdulaziz, Ahmed S Aljudia Hassan, Mohammed N Alhadi Naif
Orthopedics and Traumatology, Prince Mutaib Bin Abdulaziz Hospital, Sakaka, SAU.
Cureus. 2025 Feb 26;17(2):e79692. doi: 10.7759/cureus.79692. eCollection 2025 Feb.
Chronic Achilles tendinopathy is a debilitating condition that significantly affects mobility and quality of life. Platelet-rich plasma (PRP) therapy has been proposed as a treatment option, leveraging growth factors to promote tendon healing, but its effectiveness remains unclear. This review aimed to evaluate the effectiveness of PRP in reducing pain, improving function, and facilitating recovery in chronic Achilles tendinopathy. A total of 13 studies involving 697 patients were analyzed. Key outcomes included pain reduction (measured by visual analog scale {VAS}), functional improvement (Victorian Institute of Sports Assessment-Achilles {VISA-A}), return to activity, and patient satisfaction. Study variability was analyzed using heterogeneity measures. PRP demonstrated significant pain reduction (pooled mean VAS: 71.24, 95% CI: 53.06-89.42). Functional improvement was observed (VISA-A scores: 35.10-86.80). On average, 85% of patients returned to activity (95% CI: 65-98%) and 72% reported satisfaction (95% CI: 51-88%). High heterogeneity (I²=97%) was noted, likely due to variability in PRP preparation and treatment protocols. PRP offers promise as a treatment for chronic Achilles tendinopathy, with evidence of pain relief and functional improvement. However, variability in outcomes emphasizes the need for standardized approaches to its use and further research to better define its role in clinical practice.
慢性跟腱病是一种使人衰弱的病症，会显著影响活动能力和生活质量。富血小板血浆（PRP）疗法已被提议作为一种治疗选择，利用生长因子促进肌腱愈合，但其有效性仍不明确。本综述旨在评估PRP在减轻慢性跟腱病疼痛、改善功能和促进恢复方面的有效性。共分析了涉及697例患者的13项研究。主要结果包括疼痛减轻（通过视觉模拟量表{VAS}测量）、功能改善（维多利亚运动评估机构 - 跟腱{VISA - A}）、恢复活动情况和患者满意度。使用异质性测量方法分析研究的变异性。PRP显示出显著的疼痛减轻（合并平均VAS：71.24，95%置信区间：53.06 - 89.42）。观察到功能有所改善（VISA - A评分：35.10 - 86.80）。平均而言，85%的患者恢复了活动（95%置信区间：65 - 98%），72%的患者表示满意（95%置信区间：51 - 88%）。注意到存在高度异质性（I² = 97%），可能是由于PRP制备和治疗方案的差异所致。PRP作为慢性跟腱病的一种治疗方法具有前景，有减轻疼痛和改善功能的证据。然而，结果的变异性强调了需要标准化的使用方法以及进一步研究以更好地确定其在临床实践中的作用。
