沙特阿拉伯药品合理使用（QUM）计划与策略的有效性：一项叙述性综述
Effectiveness of Quality Use of Medicines (QUM) Programs and Strategies in Saudi Arabia: A Narrative Review.
作者信息
Aldhafeeri Fahad, Wilson Andrew, Larkin Shaun, Aldhafeeri Faisal Murayh
机构信息
Leeder Centre for Health Policy, Economics and Data, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Hafer Al Batin Health Cluster, Ministry of Health, Hafer Al Batin, Saudi Arabia.
出版信息
Drug Healthc Patient Saf. 2025 Mar 24;17:87-96. doi: 10.2147/DHPS.S503383. eCollection 2025.
BACKGROUND
The high prevalence of chronic diseases, workforce challenges, and growing polypharmacy adversely impact the quality use of medicines (QUM) and health outcomes in Saudi Arabia (SA). The SA Ministry of Health (MOH) has initiated several programs and policies to enhance QUM including a National Medication Safety Program, national clinical guidelines, and technology-based strategies.
OBJECTIVE
To assess the published literature on the range, quality, and effectiveness of QUM methods in the SA health system.
METHODS
Comprehensive search of electronic databases Scopus, Medline, and PubMed for papers reporting evaluation of QUM interventions or programs in SA.
RESULTS
QUM programs involving medication reconciliation, interventions by hospital pharmacists, antibiotics stewardship, technology and staff training are the most commonly used programs reported in SA. Evaluations of several QUM interventions found a significant positive impact on health outcomes, prescribing patterns, chronic disease management, medication safety, and healthcare costs. Medication reconciliation programs reduced discrepancies by up to 20% in some studies. Hospital pharmacist interventions showed high acceptance rates (up to 92%) and improved medication safety. Antibiotic stewardship programs effectively reduced antimicrobial use and costs. Health information technology implementations like electronic health records (EHR), and computerized physician order entry (CPOE) showed mixed results but generally improved medication safety and efficiency. Staff training initiatives enhanced healthcare professionals' knowledge and skills in medication management.
CONCLUSION
While SA has national QUM policies and programs, and evidence that individual QUM interventions have significant positive local impact, more large-scale, multi-center studies are needed to provide a comprehensive view of QUM practices. More rigorous evaluations of existing programs and expansion of the range of QUM programs to align with international ones could further improve medication safety and patient outcomes in Saudi Arabia.
背景
慢性病的高患病率、劳动力挑战以及日益增加的多重用药情况对沙特阿拉伯（SA）的药品合理使用（QUM）和健康结果产生了不利影响。沙特阿拉伯卫生部（MOH）已启动多项计划和政策来加强QUM，包括国家药物安全计划、国家临床指南和基于技术的战略。
目的
评估关于沙特阿拉伯卫生系统中QUM方法的范围、质量和有效性的已发表文献。
方法
全面检索电子数据库Scopus、Medline和PubMed，以查找报告沙特阿拉伯QUM干预措施或计划评估的论文。
结果
在沙特阿拉伯报告的最常用的QUM计划包括药物重整、医院药剂师的干预、抗生素管理、技术和人员培训。对多项QUM干预措施的评估发现，对健康结果、处方模式、慢性病管理、药物安全和医疗成本有显著的积极影响。在一些研究中，药物重整计划将差异减少了高达20%。医院药剂师的干预显示出高接受率（高达92%）并改善了药物安全。抗生素管理计划有效地减少了抗菌药物的使用和成本。电子健康记录（EHR）和计算机化医师医嘱录入（CPOE）等健康信息技术的实施结果不一，但总体上改善了药物安全和效率。人员培训举措提高了医疗保健专业人员在药物管理方面的知识和技能。
结论
虽然沙特阿拉伯有国家QUM政策和计划，且有证据表明个别QUM干预措施在当地有显著的积极影响，但需要更多大规模、多中心的研究来全面了解QUM实践。对现有计划进行更严格的评估，并扩大QUM计划的范围以与国际计划接轨，可能会进一步提高沙特阿拉伯的药物安全和患者结果。
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