Caproni Stefano, Di Fonzo Alessio, Colosimo Carlo
Neurology Division and Stroke Unit, Neuroscience Department, Santa Maria University Hospital, Terni, Italy.
Neurology Unit, Neuroscience and Mental Health Department, IRCCS Ca' Granda Ospedale Maggiore Policlinico Hospital, Milan, Italy.
Parkinsons Dis. 2025 Mar 21;2025:6691390. doi: 10.1155/padi/6691390. eCollection 2025.
Oxidative stress (OS), a condition that occurs when the balance between reactive oxygen species production and antioxidant defense mechanisms is disrupted, has been implicated in the pathogenesis of several neurological conditions, including neurodegenerative and vascular disorders. Ferroptosis is a mechanism mediating OS-induced damage, with growing evidence of specific involvement in both Parkinson's disease (PD) and ischemic stroke. Regular physical activity may have an antioxidant effect by increasing the production and activity of nonenzymatic and enzymatic antioxidants. Among the biological mediators of physical activity, irisin may act as an agent capable of inducing systemic changes and crossing the brain-blood barrier. This review aims to describe the main role of OS in the pathophysiology of PD, highlighting putative neurodegenerative mechanisms and emphasizing the potential targeting by physical activity as a possible shared preventive and symptomatic treatment approach.
氧化应激（OS）是一种当活性氧生成与抗氧化防御机制之间的平衡被打破时出现的状态，它与包括神经退行性疾病和血管疾病在内的多种神经系统疾病的发病机制有关。铁死亡是一种介导氧化应激诱导损伤的机制，越来越多的证据表明它在帕金森病（PD）和缺血性卒中中都有特定作用。规律的体育活动可能通过增加非酶和酶类抗氧化剂的生成及活性而产生抗氧化作用。在体育活动的生物介质中，鸢尾素可能作为一种能够诱导全身变化并穿过血脑屏障的介质发挥作用。本综述旨在描述氧化应激在帕金森病病理生理学中的主要作用，突出假定的神经退行性机制，并强调体育活动作为一种可能的共同预防和对症治疗方法的潜在靶向作用。
