Vance David E, Lang Lang, Maki Pauline M, Yu Danyang, Dastgheyb Raha, Wang Yuezhe, Springer Gayle, Anastos Kathryn, Gustafson Deborah R, Weber Kathleen M, Dykxhoorn Derek M, Milam Joel, Diaz Monica M, Kassaye Seble G, Waldrop Drenna, Xu Yanxun, Rubin Leah H
University of Alabama at Birmingham.
Johns Hopkins University.
Res Sq. 2025 Mar 10:rs.3.rs-6136690. doi: 10.21203/rs.3.rs-6136690/v1.
In the Women's Interagency HIV Study, we examined the association between objective cognitive test performance and the self-rated Lawton and Brody scale of Independent Activities of Daily Living (IADL) in 754 older (50+) women with HIV (WWH; 84% virally suppressed). To handle this longitudinal data, weighted logistic mixed effect models examined associations between cognitive domain performance (predictor) and functional outcomes (IADL item level scores). In the total sample, poorer motor performance was associated with impairments in , , and and poorer executive functioning was associated with impairment in . Among older virally suppressed-WWH, poorer motor performance was associated with deficits in and poorer executive performance was associated with deficits in . Since motor and executive performance were related to impairments in certain IADLs, strategies such as cognitive training targeting these domains could improve everyday functioning.
在女性机构间HIV研究中，我们调查了754名年龄较大（50岁以上）的感染HIV的女性（HIV感染女性；84%病毒得到抑制）的客观认知测试表现与自评的洛顿和布罗迪日常生活独立活动量表（IADL）之间的关联。为处理这些纵向数据，加权逻辑混合效应模型检验了认知领域表现（预测因素）与功能结局（IADL项目水平得分）之间的关联。在总样本中，较差的运动表现与[具体三项内容]的损伤相关，较差的执行功能与[具体一项内容]的损伤相关。在病毒得到抑制的老年HIV感染女性中，较差的运动表现与[具体一项内容]的缺陷相关，较差的执行表现与[具体一项内容]的缺陷相关。由于运动和执行表现与某些IADL的损伤有关，针对这些领域的认知训练等策略可能会改善日常功能。
