感染艾滋病毒女性日常功能的认知预测因素：来自女性机构间艾滋病毒研究的结果

Cognitive predictors of everyday functioning in women with HIV: findings from the women's interagency HIV study.

作者信息

Vance David E, Lang Lang, Maki Pauline M, Yu Danyang, Dastgheyb Raha, Wang Yuezhe, Springer Gayle, Anastos Kathryn, Gustafson Deborah R, Weber Kathleen M, Dykxhoorn Derek M, Milam Joel, Diaz Monica M, Kassaye Seble G, Waldrop Drenna, Xu Yanxun, Rubin Leah H

机构信息

School of Nursing, University of Alabama at Birmingham, Birmingham, AL, 35294-1210, United States of America.

Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USA.

出版信息

BMC Neurol. 2025 Aug 2;25(1):317. doi: 10.1186/s12883-025-04249-7.

DOI:10.1186/s12883-025-04249-7

PMID:40753211

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12318382/

Abstract

BACKGROUND

As the number of older people with HIV is expected to grow and experience age-related cognitive declines, concerns mount that such existing cognitive impairments may become exacerbated in already cognitively vulnerable subgroups such as women with HIV. These cognitive impairments can develop into everyday functional impairment in either basic or instrumental activities of daily living.

METHODS

In the Women's Interagency HIV Study, we examined the association between objective cognitive test performance and the self-rated Lawton and Brody scale of Independent Activities of Daily Living (IADL) in 754 older (50+) women with HIV (WWH; 84% virally suppressed). To handle this longitudinal data, weighted logistic mixed effect models examined associations between cognitive domain performance (predictor) and functional outcomes (IADL item level scores).

RESULTS

In the total sample, poorer motor performance was associated with impairments in home repairs, housekeeping, and laundry and poorer executive functioning was associated with impairment in planning social activities. Among older virally suppressed-WWH, poorer motor performance was associated with deficits in home repair and poorer executive performance was associated with deficits in planning social activities.

CONCLUSION

Since motor and executive performance were related to impairments in certain IADLs, strategies such as cognitive training targeting these domains could improve everyday functioning. Such approaches could improve autonomy as WWH age.

摘要

背景

随着感染艾滋病毒的老年人数量预计会增加，且会出现与年龄相关的认知衰退，人们越来越担心，在诸如感染艾滋病毒的女性等认知上本就脆弱的亚组人群中，现有的认知障碍可能会加剧。这些认知障碍可能会发展为日常生活基本活动或工具性活动中的日常功能障碍。

方法

在女性机构间艾滋病毒研究中，我们调查了754名年龄较大（50岁及以上）的感染艾滋病毒的女性（艾滋病毒感染女性；84%病毒得到抑制）的客观认知测试表现与自我评定的洛顿和布罗迪日常生活独立活动量表（IADL）之间的关联。为处理这些纵向数据，加权逻辑混合效应模型检验了认知领域表现（预测因素）与功能结果（IADL项目水平得分）之间的关联。