Khamidov D Kh, Abliaeva N Kh, Koval' T Iu
Biull Eksp Biol Med. 1985 Jun;99(6):696-7.
The content of cytochromes c + c1, b and a in brain and liver mitochondria in 7-day-old rats reaches the level seen in adult animals. Administration of L-T4 in a dose of 0.7 micrograms/g rat bw for 4 days before sacrifice results in activation of cytochrome synthesis in both test organs within the first week of the suckling rats' life. On the 20th day of the postnatal period the effect of T4 is seen only in the liver while the brain tissue turns out indifferent to the thyroid hormone. Thus, T4 activates cytochrome biosynthesis in brain mitochondria during the first week of the rats' life, that leads to the acceleration of the functional activity and higher differentiation of the developing brain mitochondria.
7日龄大鼠脑和肝线粒体中细胞色素c + c1、b和a的含量达到成年动物的水平。在处死前4天以0.7微克/克大鼠体重的剂量给予L-T4，导致在乳鼠生命的第一周内，两个受试器官中的细胞色素合成均被激活。在出生后第20天，T4的作用仅在肝脏中可见，而脑组织对甲状腺激素无反应。因此，T4在大鼠生命的第一周激活脑线粒体中的细胞色素生物合成，这导致发育中的脑线粒体功能活动加速和更高程度的分化。
