Fairbairn A F, Rowell F J, Hui S M, Hassanyeh F, Robinson A J, Eccleston D
Br J Psychiatry. 1983 Jun;142:579-83. doi: 10.1192/bjp.142.6.579.
Using radioimmunoassay techniques, serum levels of depot neuroleptics, fluphenazine and flupenthixol, were estimated in two groups of chronic schizophrenic patients with, and without, tardive dyskinesia. There were high significant difference in dose-related serum levels of either drug between the groups. The hypothesis that patients with tardive dyskinesia develop the syndrome because they do not metabolise neuroleptics as efficiently as those without the syndrome was not supported by the data.
采用放射免疫分析技术，对两组患有和未患迟发性运动障碍的慢性精神分裂症患者的长效抗精神病药物、氟奋乃静和三氟噻吨的血清水平进行了评估。两组间任一药物与剂量相关的血清水平存在高度显著差异。迟发性运动障碍患者发生该综合征是因为他们对抗精神病药物的代谢效率不如无该综合征患者这一假设未得到数据支持。
