神经性厌食症患者中低聚体与多聚体口服营养补充剂消化耐受性的比较。一项随机交叉临床试验。

Comparison of the digestive tolerance of an oligomeric versus a polymeric oral nutritional supplement in people with anorexia nervosa. A randomised crossover clinical trial.

作者信息

Ruiz García Ignacio, Porras Pérez Nuria, García Torres Francisca, Olivas Delgado Lourdes, Sánchez Torralvo Francisco José, Pascual López Margarita, Fernández Marzalo Carmen, Olveira Gabriel

机构信息

Servicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Malaga, Spain.

Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga, Spain.

出版信息

Eur J Clin Nutr. 2025 Mar 31. doi: 10.1038/s41430-025-01608-y.

DOI:10.1038/s41430-025-01608-y

PMID:40164776

Abstract

BACKGROUND

Most people with anorexia nervosa (pAN) have digestive symptoms, which affect tolerance to nutritional treatment. Oligomeric oral nutritional supplements may be better absorbed and tolerated than polymeric ones. Our aim was to compare an oligomeric versus a polymeric nutritional supplement in pAN in terms of worsening of digestive symptoms after ingestion (primary objective) and in terms of sensory perception of the supplement (secondary objective).

METHODS

A randomised, crossover, double-blind, controlled clinical trial was conducted. Inclusion criteria were: male or female aged 12-50 years with anorexia nervosa treated at the Eating Disorders Unit of the Hospital Regional Universitario de Málaga, Spain. Participants were randomised to first receive one container of the oligomeric or polymeric supplement. A digestive symptom questionnaire was administered, which they completed again after taking the supplement, together with a questionnaire for sensory evaluation of the supplement. One week later, they received a container of the other type of supplement, and the process was repeated. Analysis was performed on a per protocol basis.

RESULTS

Ten people were randomised to the oligomeric-polymeric sequence and 12 to the polymeric-oligomeric sequence, of whom 9 and 11, respectively, finally received the intervention and were analysed. There were no statistically significant differences in digestive symptoms between the two supplements. The oligomeric one scored lower on taste and higher on acidity. The median (interquartile range) for oligomeric and polymeric were respectively: taste 6.5 (4), 8(3), p 0.03; acidity 0 (1), 0 (0), p 0.01.

CONCLUSIONS

In pAN, there is no difference in the worsening of digestive symptoms after ingestion of oligomeric versus polymeric supplements. Polymerics are perceived as having better taste and less acidity.

TRIAL REGISTRATION

The trial is registered at ClinicalTrials.gov, number NCT05184738.

摘要

背景

大多数神经性厌食症患者（pAN）有消化症状，这会影响对营养治疗的耐受性。低聚口服营养补充剂可能比聚合型营养补充剂吸收更好且耐受性更佳。我们的目的是比较低聚型与聚合型营养补充剂在pAN患者中摄入后消化症状恶化情况（主要目标）以及补充剂的感官感知方面（次要目标）。

方法

进行了一项随机、交叉、双盲、对照临床试验。纳入标准为：年龄在12 - 50岁的男性或女性，在西班牙马拉加大学区域医院饮食失调科接受神经性厌食症治疗。参与者被随机分配首先接受一盒低聚型或聚合型补充剂。发放一份消化症状问卷，他们在服用补充剂后再次填写，同时还有一份补充剂感官评价问卷。一周后，他们接受另一类型补充剂的一盒，然后重复该过程。按方案进行分析。

结果

10人被随机分配到低聚 - 聚合序列，12人被分配到聚合 - 低聚序列，其中分别有9人和11人最终接受了干预并进行分析。两种补充剂在消化症状方面无统计学显著差异。低聚型在味道方面得分较低，在酸度方面得分较高。低聚型和聚合型的中位数（四分位间距）分别为：味道6.5（4），8（3），p = 0.03；酸度0（1），0（0），p = 0.01。