地塞米松诱导兔棕色脂肪组织变白：瘦素抵抗和线粒体功能障碍。
Dexamethasone-induced whitening of rabbit brown adipose tissue: leptin resistance and mitochondrial dysfunction.
作者信息
Tang Xiaoqin, Zhang Beibei, Xie Puhang, Wei Yanpei, Qiu Yanbo, Yi Xiaohua, Zhang Ziru, She Muzi, Sun Xiuzhu, Wang Shuhui
机构信息
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
College of Grassland Agriculture, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
出版信息
BMC Genomics. 2025 Mar 31;26(1):326. doi: 10.1186/s12864-025-11502-3.
BACKGROUND
Research on the effects of exogenous glucocorticoids on brown adipose tissue (BAT) is crucial for understanding how these hormones can induce metabolic disorders such as obesity. In this study, we explored the effects of glucocorticoids, specifically dexamethasone (Dex), on the metabolic transformation of BAT to white adipose tissue (WAT).
RESULTS
Our results indicate a significant whitening shift in BAT upon Dex treatment, characterized by increased lipid deposition, decreased mitochondrial density, a significant decline in cellular ATP content, and reduced expression of mitochondrial markers. We demonstrate the crucial role of leptin resistance in mediating mitochondrial function through the overexpression and inhibition of LEPR.
CONCLUSIONS
Our results suggest the role of leptin resistance in regulating of mitochondrial biogenesis and energy metabolism in glucocorticoid-induced brown adipose whiteness.
背景
研究外源性糖皮质激素对棕色脂肪组织（BAT）的影响对于理解这些激素如何引发肥胖等代谢紊乱至关重要。在本研究中，我们探究了糖皮质激素，特别是地塞米松（Dex），对BAT向白色脂肪组织（WAT）代谢转化的影响。
结果
我们的结果表明，Dex处理后BAT出现显著的白化转变，其特征为脂质沉积增加、线粒体密度降低、细胞ATP含量显著下降以及线粒体标志物表达减少。我们通过过表达和抑制LEPR证明了瘦素抵抗在介导线粒体功能中的关键作用。
结论
我们的结果表明，瘦素抵抗在糖皮质激素诱导的棕色脂肪白化过程中调节线粒体生物发生和能量代谢方面发挥作用。
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