Wan Wei, Hua Fuzhou, Fang Pu, Li Chang, Deng Fumou, Chen Shoulin, Ying Jun, Wang Xifeng
Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China.
Front Aging Neurosci. 2022 May 9;14:845330. doi: 10.3389/fnagi.2022.845330. eCollection 2022.
Sirtuins are protein factors that can delay aging and alleviate age-related diseases through multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere shortening, and mediating the longevity effect of caloric restriction. In the last decade, sirtuins have also been suggested to exert mitochondrial quality control by mediating mitophagy, which targets damaged mitochondria and delivers them to lysosomes for degradation. This is especially significant for age-related diseases because dysfunctional mitochondria accumulate in aging organisms. Accordingly, it has been suggested that sirtuins and mitophagy have many common and interactive aspects in the aging process. This article reviews the mechanisms and pathways of sirtuin family-mediated mitophagy and further discusses its role in aging and age-related diseases.
沉默调节蛋白是一类蛋白质因子，可通过多种分子途径延缓衰老并减轻与年龄相关的疾病，主要是通过促进DNA损伤修复、延缓端粒缩短以及介导热量限制的长寿效应。在过去十年中，也有人提出沉默调节蛋白可通过介导线粒体自噬来实现线粒体质量控制，线粒体自噬靶向受损线粒体并将其输送到溶酶体进行降解。这对于与年龄相关的疾病尤为重要，因为功能失调的线粒体在衰老生物体中会积累。因此，有人提出沉默调节蛋白和线粒体自噬在衰老过程中有许多共同和相互作用的方面。本文综述了沉默调节蛋白家族介导的线粒体自噬的机制和途径，并进一步讨论了其在衰老和与年龄相关疾病中的作用。
