Mitchell A, Collin J
Br J Surg. 1985 Jun;72(6):462-5. doi: 10.1002/bjs.1800720620.
Experiments were performed on luminally perfused, isolated, canine, jejunal segments in vivo to determine the effects of vasopressin on intestinal motility, myoelectrical activity and absorption. Intravenous vasopressin abolished spike activity and sometimes disrupted slow wave activity. The jejunum became atonic with intraluminal pooling of perfusate. Transit time was prolonged and intestinal absorption of water was decreased. Radionuclide imaging of the intestinal contents showed a doubling of intraluminal volume with vasopressin and confirmed the loss of intestinal motility. It is suggested that the high plasma levels of vasopressin which are known to follow laparotomy may be a factor in the development of postoperative ileus.
对体内经腔内灌注的犬离体空肠段进行实验，以确定血管加压素对肠道运动、肌电活动和吸收的影响。静脉注射血管加压素可消除锋电位活动，有时还会破坏慢波活动。空肠变得无张力，灌注液在腔内积聚。转运时间延长，肠道对水的吸收减少。肠道内容物的放射性核素成像显示，使用血管加压素后腔内体积增加了一倍，并证实了肠道运动的丧失。有人提出，已知剖腹手术后会出现的高血浆血管加压素水平可能是术后肠梗阻发生的一个因素。
