Soni Krishna, Kaur Harvinder, Gupta Anju, Singh Surjit, Saha Subhas C, Bhalla Anil
Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.
Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.
Cureus. 2025 Feb 28;17(2):e79861. doi: 10.7759/cureus.79861. eCollection 2025 Feb.
Objective Growth failure is an often overlooked complication of juvenile dermatomyositis (JDMS) hence, the present study analyses the auxological status of adolescent JDMS patients. Methods Sixty serial observations with respect to height, weight, and skinfold thicknesses were made on 35 JDMS children aged 10 to 17 years in the Growth Laboratory/Clinic of the Department following a mixed-longitudinal growth research design. Information with regard to disease duration and disease activity (MMT-8 score) was recorded. Results The mean height and weight of JDMS patients showed a regular increase from 10 to 17 years while BMI depicted an undulating pattern. JDMS boys were taller yet weighed lighter and had lesser sub-cutaneous fat deposition than girls. As compared to their normal counterparts, JDMS children were lighter and shorter, however, JDMS girls caught up and became heavier and taller beyond 12 and 14 years, respectively. Only 4 (6.6%) and 5 (8.33%) of our study subjects were short-statured and underweight, respectively. Disease activity had a significant positive correlation with the physical growth of JDMS boys. Conclusion JDMS boys depicted compromised growth when contrasted with their unaffected counterparts; this may be due to the influence of disease activity on their physical growth. However, better auxological prognosis recorded for JDMS girls beyond 12-13 years reveals that there must be some protective mechanism favoring girls making them resistant to adverse effects of the disease.
目的 生长发育迟缓是幼年皮肌炎（JDMS）一种常被忽视的并发症，因此，本研究分析了青少年JDMS患者的体格发育状况。方法 按照混合纵向生长研究设计，在该科室的生长实验室/诊所对35名年龄在10至17岁的JDMS儿童进行了60次关于身高、体重和皮褶厚度的连续观察。记录了疾病持续时间和疾病活动度（MMT-8评分）的信息。结果 JDMS患者的平均身高和体重在10至17岁期间呈规律性增长，而体重指数呈现出波动模式。JDMS男孩比女孩更高，但体重更轻，皮下脂肪沉积更少。与正常同龄人相比，JDMS儿童体重更轻、身高更矮，然而，JDMS女孩分别在12岁和14岁之后追赶上来，体重变得更重、身高变得更高。在我们的研究对象中，分别只有4名（6.6%）和5名（8.33%）身材矮小和体重过轻。疾病活动度与JDMS男孩的身体生长呈显著正相关。结论 与未受影响的同龄人相比，JDMS男孩的生长发育受到影响；这可能是由于疾病活动度对其身体生长的影响。然而，JDMS女孩在12 - 13岁之后有更好的体格发育预后，这表明一定存在某种保护机制有利于女孩，使她们对疾病的不良影响具有抵抗力。
