Tu Fulai, Tu Zhengcheng, Jiang Xinrui, Zhao Meng, Li Wei, Wu Chunfeng, Wei Pingmin
Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu, China.
Olin Business School, Washington University in St. Louis, MO, United States.
Front Neurol. 2025 Mar 17;16:1548477. doi: 10.3389/fneur.2025.1548477. eCollection 2025.
This systematic analysis aims to elucidate the trends and burden of idiopathic epilepsy among children aged 0 to 14 from 1990 to 2021, utilizing Global Burden of Disease (GBD) 2021 data to explore demographic and geographical variations, highlight progress, and identify ongoing challenges.
Data were sourced from the GBD 2021 database, focusing on children aged 0-14. Annual absolute numbers and age-standardized rates for incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (ASDR) of idiopathic epilepsy were retrieved. Joinpoint regression analyses assessed changes over time, calculating average annual percentage change (AAPC) statistics. Data collation and visualizations were conducted using R software, with statistical significance established at a -value threshold of 0.05.
In 2021, there were 1,227,191 incident cases, 6,095,769 prevalent cases, 3,564,497 DALYs, and 18,171 deaths due to idiopathic epilepsy globally. The ASIR increased by 0.27% from 55.74 to 61.35 per 100,000 population from 1990 to 2021. In contrast, ASPR (AAPC = -0.03), ASMR (AAPC = -1.60), and ASDR (AAPC = -1.01) all decreased. Regionally, the low-middle SDI region had the highest burden, while the high SDI region had the highest ASIR and ASPR. The low SDI region experienced the highest ASMR and ASDR. Significant regional variations were noted, with the African Region exhibiting the highest ASIR and ASDR, while the Western Pacific Region had the lowest. Nationally, substantial variations were observed across 204 countries, with notable differences in ASIR, ASPR, ASMR, and ASDR.
Despite overall declines in ASPR, ASMR, and ASDR, the slight increase in ASIR and regional disparities highlight ongoing challenges. Low and low-middle SDI regions continue to bear a higher burden, underscoring the need for targeted interventions and improved healthcare access. Future efforts should focus on strengthening healthcare systems, enhancing diagnostic and treatment capabilities, and increasing awareness, particularly in resource-limited regions.
本系统分析旨在阐明1990年至2021年0至14岁儿童特发性癫痫的趋势和负担，利用全球疾病负担（GBD）2021数据探索人口统计学和地理差异，突出进展，并确定持续存在的挑战。
数据来源于GBD 2021数据库，重点关注0 - 14岁儿童。检索特发性癫痫的年绝对数以及发病率（ASIR）、患病率（ASPR）、死亡率（ASMR）和伤残调整生命年（ASDR）的年龄标准化率。连接点回归分析评估随时间的变化，计算年均百分比变化（AAPC）统计数据。使用R软件进行数据整理和可视化，以0.05的P值阈值确定统计学显著性。
2021年，全球因特发性癫痫有1,227,191例新发病例、6,095,769例现患病例、3,564,497个伤残调整生命年以及18,171例死亡。从1990年到2021年，ASIR从每10万人55.74例增加到61.35例，增幅为0.27%。相比之下，ASPR（AAPC = -0.03）、ASMR（AAPC = -1.60）和ASDR（AAPC = -1.01）均有所下降。在区域层面，中低社会人口指数（SDI）区域负担最高，而高SDI区域ASIR和ASPR最高。低SDI区域ASMR和ASDR最高。观察到显著的区域差异，非洲区域ASIR和ASDR最高，而西太平洋区域最低。在国家层面，在204个国家中观察到很大差异，ASIR、ASPR、ASMR和ASDR存在显著差异。
尽管ASPR、ASMR和ASDR总体下降，但ASIR的轻微上升和区域差异凸显了持续存在的挑战。低和中低SDI区域负担仍然较高，这突出了有针对性干预措施和改善医疗服务可及性的必要性。未来的努力应集中在加强医疗系统、提高诊断和治疗能力以及提高认识，特别是在资源有限的地区。
