Li Xin-Yu, Kong Xiang-Meng, Yang Cheng-Hao, Cheng Zhi-Feng, Lv Jia-Jie, Guo Hong, Liu Xiao-Hong
Department of Neurology, Shanghai Putuo People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
EClinicalMedicine. 2024 Jul 27;75:102758. doi: 10.1016/j.eclinm.2024.102758. eCollection 2024 Sep.
Ischemic stroke remains a major contributor to global mortality and morbidity. This study aims to provide an updated assessment of rates in ischemic stroke prevalence, incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021, specifically focusing on including prevalence investigation alongside other measures. The analysis is stratified by sex, age, and socio-demographic index (SDI) at global, regional, and national levels.
Data for this study was obtained from the 2021 Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). To quantify temporal patterns and assess trends in age-standardized rates of ischemic stroke prevalence (ASPR), incidence (ASIR), mortality (ASDR), and DALYs, estimated annual percentage changes (EAPCs) were computed over the study period. The analyses were disaggregated by gender, 20 age categories, 21 GBD regions, 204 nations/territories, and 5 SDI quintiles. R statistical package V 4.4.2 was performed for statistical analyses and plot illustrations.
In 2021, the global burden of ischemic stroke remained substantial, with a total of 69,944,884.8 cases with an ASPR of 819.5 cases per 100,000 individuals (95% UI: 760.3-878.7). The ASIR was 92.4 per 100,000 people (95% UI: 79.8-105.8), while the ASDR was 44.2 per 100,000 persons (95% UI: 39.3-47.8). Additionally, the age-standardized DALY rate was 837.4 per 100,000 individuals (95% UI: 763.7-905). Regionally, areas with high-middle SDI exhibited the greatest ASPR, ASIR, ASDR, and age-standardized DALY rates, whereas high SDI regions had the lowest rates. Geospatially, Southern Sub-Saharan Africa had the highest ASPR, while Eastern Europe showed the highest ASIR. The greatest ASDR and age-standardized DALY rates were observed in Eastern Europe, Central Asia, as well as North Africa, and the Middle East. Among countries, Ghana had the highest ASPR, and North Macedonia had both the highest ASIR and ASDR. Furthermore, North Macedonia also exhibited the highest age-standardized DALY rate.
Regions with high-middle and middle SDI continued to experience elevated ASPR, ASIR, ASDR and age-standardized DALY rates. The highest ischemic stroke burden was observed in Southern Sub-Saharan Africa, Central Asia, Eastern Europe, and the Middle East.
None.
缺血性中风仍是全球死亡率和发病率的主要原因。本研究旨在对1990年至2021年期间缺血性中风的患病率、发病率、死亡率和伤残调整生命年（DALYs）进行最新评估，特别侧重于将患病率调查与其他指标一起纳入。分析按全球、区域和国家层面的性别、年龄和社会人口指数（SDI）进行分层。
本研究的数据来自2021年全球疾病、伤害及风险因素负担研究（GBD）。为了量化时间模式并评估缺血性中风患病率（ASPR）、发病率（ASIR）、死亡率（ASDR）和DALYs的年龄标准化率趋势，在研究期间计算了估计年度百分比变化（EAPCs）。分析按性别、20个年龄类别、21个GBD区域、204个国家/地区和5个SDI五分位数进行分类。使用R统计软件包V 4.4.2进行统计分析和绘制图表。
2021年，全球缺血性中风负担仍然很重，共有69,944,884.8例，ASPR为每10万人819.5例（95% UI：760.3 - 878.7）。ASIR为每10万人92.4例（95% UI：79.8 - 105.8），而ASDR为每10万人44.2例（95% UI：39.3 - 47.8）。此外，年龄标准化DALY率为每10万人837.4例（95% UI：763.7 - 905）。在区域层面，中高SDI地区的ASPR、ASIR、ASDR和年龄标准化DALY率最高，而高SDI地区的这些率最低。在地理空间上，撒哈拉以南非洲南部的ASPR最高，而东欧的ASIR最高。东欧、中亚以及北非和中东的ASDR和年龄标准化DALY率最高。在国家中，加纳的ASPR最高，北马其顿的ASIR和ASDR均最高。此外，北马其顿的年龄标准化DALY率也最高。
中高和中等SDI地区的ASPR、ASIR、ASDR和年龄标准化DALY率持续升高。撒哈拉以南非洲南部、中亚、东欧和中东的缺血性中风负担最高。
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