Coon J S, McCall A, Miller A W, Farrow G M, Weinstein R S
Cancer. 1985 Aug 15;56(4):797-804. doi: 10.1002/1097-0142(19850815)56:4<797::aid-cncr2820560417>3.0.co;2-h.
Expression of epithelial ABH blood group antigens and the T (Thomsen-Friedenreich)-antigen was quantitatively studied by immunoperoxidase techniques in nine cystectomy specimens containing extensive carcinoma in situ (CIS), and also histologically benign epithelium. CIS areas typically showed abnormal expression of both ABH and T-antigens and a distinctive vascular architecture, revealed by endothelial ABH staining. Histologically normal epithelium generally was antigenically normal, but occasionally showed abnormalities of either ABH or T-antigens. Antigen expression was variable in histologically atypical epithelium, with significant segments showing abnormalities of either ABH or T-antigen, and sometimes of both antigenic markers. It is postulated that histologically benign, but antigenically abnormal, epithelium may represent low-grade CIS of the urinary bladder. Assessment of blood-group-related antigen expression in flat atypical epithelium of the urinary bladder may be useful for predicting the biologic potential of these lesions.
采用免疫过氧化物酶技术，对9例含有广泛原位癌（CIS）以及组织学上良性上皮的膀胱切除标本，进行上皮ABH血型抗原和T（汤姆森-弗里德赖希）抗原表达的定量研究。原位癌区域通常显示ABH和T抗原的异常表达以及独特的血管结构，通过内皮ABH染色可揭示这一点。组织学上正常的上皮一般抗原性正常，但偶尔会显示ABH或T抗原的异常。在组织学非典型上皮中，抗原表达存在差异，有相当一部分显示ABH或T抗原异常，有时两种抗原标志物都异常。据推测，组织学上良性但抗原性异常的上皮可能代表膀胱的低级别原位癌。评估膀胱扁平非典型上皮中与血型相关的抗原表达，可能有助于预测这些病变的生物学潜能。
