Fukatsu H, Yamada H, Nonomura H, Miyagawa Y, Waki M, Hatano Y, Hiraiwa S, Muramatsu T, Nishikawa E, Yamada Y
Department of Urology, Aichi Medical University.
Hinyokika Kiyo. 1988 Feb;34(2):260-7.
Thomsen Friedenreich antigen (T-ag), ABH isoantigen (ABH-ag) in 106 cases with bladder tumor (all transitional cell carcinoma) of various histological grades and stages were investigated by the Avidin-Biotin-Peroxidase Complex (ABC) method. There was a correlation between histological grade, stage and deletion of the antigenicity (T-ag and ABH-ag). In a follow-up study of 45 patients with low grade and low stage tumor, the recurrence rate after surgery of the cases with abnormal antigenicity (T-ag and ABH-ag) was significantly higher than that of the cases with the normal antigenicity. Combination of two markers (T-ag and ABH-ag) was significantly more effective than the single marker.
采用抗生物素蛋白-生物素-过氧化物酶复合物（ABC）法，对106例不同组织学分级和分期的膀胱肿瘤（均为移行细胞癌）中的汤姆森·弗里登赖希抗原（T抗原）、ABH同种抗原（ABH抗原）进行了研究。组织学分级、分期与抗原性缺失（T抗原和ABH抗原）之间存在相关性。在对45例低分级、低分期肿瘤患者的随访研究中，抗原性异常（T抗原和ABH抗原）病例术后的复发率显著高于抗原性正常的病例。两种标志物（T抗原和ABH抗原）联合使用比单一标志物更有效。
