Gleeson Dermot, Bornand Rosemary, Brownlee Ann, Dhaliwal Harpreet, Dyson Jessica K, Hails Janeane, Henderson Paul, Kelly Deirdre, Mells George F, Miquel Rosa, Oo Ye H, Sutton Anthea, Yeoman Andrew, Heneghan Michael A
Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
Division of Clinical Medicine, School of Medicine and Population Science, University of Sheffield, Sheffield, UK.
Gut. 2025 Aug 7;74(9):1364-1409. doi: 10.1136/gutjnl-2024-333171.
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease which, if untreated, often leads to cirrhosis, liver failure and death. The last British Society of Gastroenterology (BSG) guideline for the management of AIH was published in 2011. Since then, our understanding of AIH has advanced in many areas. This update to the previous guideline was commissioned by the BSG and developed by a multidisciplinary group. The aim of this guideline is to review and summarise the current evidence, in order to inform and guide diagnosis and management of patients with AIH and its variant syndromes. The main focus is on AIH in adults, but the guidelines should also be relevant to older children and adolescents.
自身免疫性肝炎(AIH)是一种慢性炎症性肝病,若不治疗,常导致肝硬化、肝衰竭和死亡。英国胃肠病学会(BSG)上一次发布的AIH管理指南是在2011年。自那时以来,我们对AIH的认识在许多方面都有了进展。本次对上一版指南的更新由BSG委托,并由一个多学科小组制定。本指南的目的是回顾和总结当前证据,以便为AIH及其变异综合征患者的诊断和管理提供信息并给予指导。主要重点是成人AIH,但本指南也应适用于大龄儿童和青少年。