硝苯地平和氟桂利嗪可阻断苯丙胺对小鼠行为的兴奋作用。
Nifedipine and flunarizine block amphetamine-induced behavioral stimulation in mice.
作者信息
Grebb J A
出版信息
Life Sci. 1986 Jun 30;38(26):2375-81. doi: 10.1016/0024-3205(86)90605-3.
PMID:3724362
Abstract
Sixteen calcium channel inhibitors (CCI's) were tested in a model utilizing amphetamine-induced behavioral stimulation in mice. Nifedipine, flunarizine and possibly PY 108-068 were effective in blocking amphetamine-induced locomotor stimulation. Verapamil, diltiazem and many other CCI's were ineffective in this experimental paradigm.
摘要
在一个利用苯丙胺诱导小鼠行为兴奋的模型中，对16种钙通道抑制剂（CCI）进行了测试。硝苯地平、氟桂利嗪以及可能的PY 108 - 068能有效阻断苯丙胺诱导的运动兴奋。维拉帕米、地尔硫䓬和许多其他CCI在这个实验范式中无效。
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