Gregoriou Stamatis, Stefanou Garyfallia, Kontodimas Stathis, Sfaelos Konstantinos, Zavali Maria, Vakirlis Efstratios, Kourlaba Georgia
Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, 16121 Athens, Greece.
ECONCARE, 11528 Athens, Greece.
J Clin Med. 2022 Aug 16;11(16):4777. doi: 10.3390/jcm11164777.
The objective was to describe the AD burden in terms of quality of life (QoL), sleep, social life, work productivity, and resource utilization in Greece and assess the impact of disease severity. A nationwide cross-sectional survey was conducted. The questionnaire consisted of socioeconomic factors, medical history, AD screening, AD severity, QoL, sleep difficulties, social activities, and work productivity questions. AD was defined using the UK Working Party criteria (UKWP cohort) and a patient-reported AD diagnosis from a physician (Expert Diagnosis cohort). Self-reported moderate/severe AD was estimated using the Patient-Oriented Eczema Measure (POEM). In the UKWP cohort, the AD effect on QoL was moderate/extremely large in 84.3% of moderate/severe AD (vs. 55.7% in mild; p = 0.016), while in the Expert Diagnosis cohort, it was 72.2% (vs. 22.8%; p < 0.001). Disease severity was associated with a higher impact on sleep and social activities. Overall work impairment was high in both mild (32.7%) and moderate/severe (48.5%) AD of the UKWP cohort, while among the Expert Diagnosis cohort, it was significantly higher among those with moderate/severe (31.2%) versus mild AD (11.9%; p < 0.001). The AD burden in Greece is significant, especially for those in moderate/severe AD stages. Acknowledging this burden is the first step toward applying healthcare decisions that will benefit patients and the community.
目的是从生活质量（QoL）、睡眠、社交生活、工作生产力和资源利用方面描述希腊的特应性皮炎（AD）负担，并评估疾病严重程度的影响。开展了一项全国性横断面调查。问卷包括社会经济因素、病史、AD筛查、AD严重程度、QoL、睡眠困难、社交活动和工作生产力问题。AD的定义采用英国工作组标准（UKWP队列）以及患者报告的医生诊断的AD（专家诊断队列）。使用患者导向的湿疹量表（POEM）估算自我报告的中度/重度AD。在UKWP队列中，84.3%的中度/重度AD患者中AD对QoL的影响为中度/极大（轻度患者中为55.7%；p = 0.016），而在专家诊断队列中，这一比例为72.2%（轻度患者中为22.8%；p < 0.001）。疾病严重程度与对睡眠和社交活动的更高影响相关。在UKWP队列的轻度（32.7%）和中度/重度（48.5%）AD患者中，总体工作受损程度都很高，而在专家诊断队列中，中度/重度AD患者（31.2%）的工作受损程度明显高于轻度AD患者（11.9%；p < 0.001）。希腊的AD负担很重，尤其是对于那些处于中度/重度AD阶段的患者。认识到这一负担是朝着应用将使患者和社区受益的医疗保健决策迈出的第一步。
