Kang Lijun, Gong Qian, Wang Wei, Nie Zhaowen, Yao Lihua, Xiang Dan, Tu Ning, Feng Hongyan, Wang Huiling, Wang Gaohua, Bu Lihong, Liu Zhongchun
Department of Psychiatry, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuhan, 430060, China.
PET/CT/MRI and Molecular Imaging Center, Renmin Hospital of Wuhan University, 95 Zhangzhidong Rd, Wuhan, 430060, China.
Brain Imaging Behav. 2025 Apr 2. doi: 10.1007/s11682-025-00983-1.
Major depressive disorder (MDD) exhibits a moderate degree of heritability and shares common influences with early adverse life events, as well as being associated with inconsistent changes in cerebral blood flow (CBF). Here, we investigated whether MDD polygenic risk score (PRS) and emotional neglect influences alterations in CBF. We collected blood and ASL from MDD patients. Emotional neglect (EN) assessment was performed using the Childhood Trauma Questionnaire. We calculated PRS for MDD based the MDD GWAS result in Asian populations. Subsequently, we examined the interaction between PRS for MDD and EN on CBF. Finally, 174 participated in statistical analysis. After adjusting for confounding factors, there was a significant main effect of PRS on left dorsolateral superior frontal gyrus, while the main effect of EN was not significantly (P < 0.001, GRF corrected). And significant interactive effect was found between PRS of MDD and EN on precuneus CBF (P < 0.001, GRF corrected). In MDD, high polygenic risk independently influenced changes in left dorsolateral superior frontal gyrus CBF, while EN plays a role in individuals with a higher genetic risk for MDD. Our study indicates the need to consider the combined effects of genetic risk and early adverse events on alterations in brain structure in the occurrence of MDD.
重度抑郁症（MDD）具有中度遗传性，与早期不良生活事件存在共同影响，并且与脑血流量（CBF）的不一致变化有关。在此，我们研究了MDD多基因风险评分（PRS）和情感忽视是否会影响CBF的改变。我们收集了MDD患者的血液和动脉自旋标记（ASL）数据。使用儿童创伤问卷进行情感忽视（EN）评估。我们根据亚洲人群的MDD全基因组关联研究（GWAS）结果计算MDD的PRS。随后，我们研究了MDD的PRS与EN对CBF的相互作用。最后，174名参与者进行了统计分析。在调整混杂因素后，PRS对左侧背外侧额上回有显著的主效应，而EN的主效应不显著（P < 0.001，高斯随机场（GRF）校正）。并且发现MDD的PRS与EN对楔前叶CBF有显著的交互作用（P < 0.001，GRF校正）。在MDD中，高多基因风险独立影响左侧背外侧额上回CBF的变化，而EN在MDD遗传风险较高的个体中起作用。我们的研究表明，在MDD发生过程中，需要考虑遗传风险和早期不良事件对脑结构改变的综合影响。
