Nicolau Rafaela, Pereira Luciano, Terroso Georgina, Vaz Carlos, Brito Iva, Frazão João
Viseu Dão Lafões Health Unit, Viseu, Portugal.
Faculty of Medicine, University of Porto, Portugal.
ARP Rheumatol. 2025 Jan-Mar;4(1):37-43.
Bone biopsy is the only technique capable of comprehensively assessing all bone parameters, including turnover, microarchitecture, and mineralization, yet its clinical utility is debated. This study evaluates its role in routine diagnostic and therapeutic applications.
A retrospective analysis was conducted on 22 horizontal transiliac bone biopsies from 20 patients referred for rheumatology consultation between August 2016 and May 2022. Diagnoses included osteoporosis, adynamic bone disease, hyperparathyroidism-related bone disease, and osteomalacia.
Histopathological findings led to therapeutic strategies differing from standard anti-osteoporotic treatment in over one-third of cases. In certain cases, bone biopsy provided critical diagnostic insights that guided therapeutic decisions.
Although advancements in non-invasive diagnostics exist, bone biopsy remains indispensable for a subset of patients, offering essential diagnostic and therapeutic insights that significantly influence clinical management.
骨活检是唯一能够全面评估所有骨参数的技术，包括骨转换、微结构和矿化，但它的临床实用性仍存在争议。本研究评估其在常规诊断和治疗应用中的作用。
对2016年8月至2022年5月期间因风湿病会诊而转诊的20例患者的22例水平髂骨活检进行回顾性分析。诊断包括骨质疏松症、骨动力不足性骨病、甲状旁腺功能亢进相关骨病和骨软化症。
组织病理学结果导致超过三分之一的病例的治疗策略不同于标准抗骨质疏松治疗。在某些情况下，骨活检提供了关键的诊断见解，指导了治疗决策。
尽管无创诊断技术有所进步，但骨活检对一部分患者来说仍然不可或缺，它提供了重要的诊断和治疗见解，对临床管理有重大影响。
