Haller Justin, Natoli Roman, Saiz Augustine, Wenke Joseph, O'Neill Dillon, Evans Andrew
Department of Orthopaedic Surgery, University of Utah, Salt Lake City, UT.
Department of Orthopaedic Surgery, University of Indiana, Indianapolis, IN.
OTA Int. 2025 Apr 1;8(2 Suppl):e362. doi: 10.1097/OI9.0000000000000362. eCollection 2025 Apr.
Muscle injury in the setting of orthopaedic trauma is common. Skeletal muscle injury can cause immune dysregulation and impair fracture healing both in patients and in various preclinical models. Muscle injury can also be associated with impaired vascularity and eliminate the muscle paracrine effect, both of which can impair fracture healing. Severe muscle injury can lead to volumetric muscle loss. While there are currently no effective treatments for volumetric muscle loss, minced muscle autograft has been shown to improve fracture healing, but not improve muscle function. Acute compartment syndrome can severely impact functional recovery and limit fracture healing. However, current animal models of compartment syndrome lack appropriate translation to the clinical injury.
在骨科创伤情况下，肌肉损伤很常见。骨骼肌损伤可导致免疫失调，并在患者和各种临床前模型中损害骨折愈合。肌肉损伤还可能与血管受损有关，并消除肌肉旁分泌效应，这两者都会损害骨折愈合。严重的肌肉损伤可导致肌肉体积丧失。虽然目前尚无有效的治疗肌肉体积丧失的方法，但肌肉自体碎块移植已被证明可改善骨折愈合，但不能改善肌肉功能。急性骨筋膜室综合征可严重影响功能恢复并限制骨折愈合。然而，目前骨筋膜室综合征的动物模型与临床损伤缺乏适当的转化。
