Garrido Victoria E, Outlaw William G, Powell Amanda M, Ables Elizabeth T
Biology, East Carolina University, Greenville, North Carolina, United States.
MicroPubl Biol. 2025 Mar 17;2025. doi: 10.17912/micropub.biology.001550. eCollection 2025.
Germline stem cells (GSCs) are necessary for oocyte production in . GSC maintenance is regulated by intrinsic factors that promote their self-renewal. One such factor, the beta-importin, , mediates nuclear import of serine/arginine-rich (SR) proteins, which are phosphorylated by SR protein kinases. Here, we investigate whether the kinase encoded by ( ) is essential for GSC self-renewal. We find that SRPK is expressed in GSCs and their mitotically-dividing daughters, but is not necessary for GSC establishment or maintenance. We conclude that SRPK is dispensable for GSC self-renewal, and postulate that other protein kinases can compensate for its absence.
生殖系干细胞（GSCs）对于[具体物种]的卵母细胞产生是必需的。GSC的维持受促进其自我更新的内在因素调控。其中一个这样的因素，β-输入蛋白，[此处信息缺失]，介导富含丝氨酸/精氨酸（SR）的蛋白质的核输入，这些蛋白质被SR蛋白激酶磷酸化。在这里，我们研究由[基因名称]编码的激酶（SRPK）对于GSC自我更新是否必不可少。我们发现SRPK在GSCs及其有丝分裂分裂的子代中表达，但对于GSC的建立或维持不是必需的。我们得出结论，SRPK对于GSC自我更新是可有可无的，并推测其他蛋白激酶可以弥补其缺失。
