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本文引用的文献

1
Altered DNA methylome profiles of blood leukocytes in Chinese patients with mild cognitive impairment and Alzheimer's disease.中国轻度认知障碍和阿尔茨海默病患者血液白细胞的DNA甲基化组图谱改变
Front Genet. 2023 Jun 14;14:1175864. doi: 10.3389/fgene.2023.1175864. eCollection 2023.
2
A Preliminary Comparison of the Methylome and Transcriptome from the Prefrontal Cortex Across Alzheimer's Disease and Lewy Body Dementia.阿尔茨海默病和路易体痴呆患者前额叶皮质甲基化组与转录组的初步比较
J Alzheimers Dis Rep. 2023 Apr 20;7(1):279-297. doi: 10.3233/ADR220114. eCollection 2023.
3
Gene Set Based Integrated Methylome and Transcriptome Analysis Reveals Potential Molecular Mechanisms Linking Cigarette Smoking and Related Diseases.基于基因集的整合甲基化组和转录组分析揭示了吸烟与相关疾病关联的潜在分子机制。
OMICS. 2023 May;27(5):193-204. doi: 10.1089/omi.2023.0028. Epub 2023 May 5.
4
Genes implicated by a methylome-wide schizophrenia study in neonatal blood show differential expression in adult brain samples.一项针对新生儿血液进行的全甲基化组精神分裂症研究中涉及的基因，在成人大脑样本中呈现出差异表达。
Mol Psychiatry. 2023 May;28(5):2088-2094. doi: 10.1038/s41380-023-02080-5. Epub 2023 Apr 27.
5
CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder.人类皮质神经元中的CpH甲基化组分析确定了阿片类药物使用障碍的新基因途径和药物靶点。
Front Psychiatry. 2023 Jan 19;13:1078894. doi: 10.3389/fpsyt.2022.1078894. eCollection 2022.
6
Methylome-wide association study of different responses to risperidone in schizophrenia.精神分裂症患者对利培酮不同反应的全基因组甲基化关联研究。
Front Pharmacol. 2022 Dec 22;13:1078464. doi: 10.3389/fphar.2022.1078464. eCollection 2022.
7
Mammalian DNA methylome dynamics: mechanisms, functions and new frontiers.哺乳动物 DNA 甲基组动态：机制、功能与新前沿。
Development. 2022 Dec 15;149(24). doi: 10.1242/dev.182683.
8
Elevated exposures to persistent endocrine disrupting compounds impact the sperm methylome in regions associated with autism spectrum disorder.接触高水平的持久性内分泌干扰化合物会影响与自闭症谱系障碍相关区域的精子甲基化组。
Front Genet. 2022 Aug 11;13:929471. doi: 10.3389/fgene.2022.929471. eCollection 2022.
9
Methylome-wide Association Study of Patients with Recent-onset Psychosis.近期发病精神病患者的全基因组甲基化关联研究。
Clin Psychopharmacol Neurosci. 2022 Aug 31;20(3):462-473. doi: 10.9758/cpn.2022.20.3.462.
10
DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses.全基因组 DNA 甲基化关联研究遗传风险抑郁症表明抗原加工和免疫反应。
Genome Med. 2022 Mar 31;14(1):36. doi: 10.1186/s13073-022-01039-5.

精神疾病的全基因组甲基化关联研究。

Methylome-wide association studies of psychiatric disorders.

作者信息

Mao Qiao, Luo Zhixiong, Wang Xiaoping, Wang Kesheng, Wang Zhiren, Zhang Yong, Luo Xingguang

机构信息

Department of Psychosomatic Medicine, People's Hospital of Deyang City, Deyang, Sichuan 618000, China.

College of Integrative Medicine, Fujian University of Traditional Medicine, Fuzhou 350122, China.

出版信息

EC Psychol Psychiatr. 2024;2024. Epub 2024 Aug 2.

PMID:40171497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11960846/
Abstract

Neuroepigenetics underscores the significance of the methylome in both normal and pathological brain function, influencing neurobiological processes and psychiatric well-being. This study systematically examines methylome-wide association studies (MWAS) across various psychiatric disorders that utilize array-based and sequencing approaches on blood or brain tissue samples. The findings provide valuable insights into the early stages of neuropathogenesis in psychiatric disorders, revealing altered epigenetic mechanisms. The methylome emerges as a pivotal factor in the development and treatment of psychiatric conditions, potentially offering avenues for identifying therapeutic targets and informing treatment strategies.

摘要

神经表观遗传学强调了甲基化组在正常和病理性脑功能中的重要性，影响着神经生物学过程和精神健康。本研究系统地考察了针对各种精神障碍的全甲基化组关联研究（MWAS），这些研究在血液或脑组织样本上采用了基于芯片和测序的方法。研究结果为精神障碍神经发病机制的早期阶段提供了有价值的见解，揭示了表观遗传机制的改变。甲基化组成为精神疾病发展和治疗中的关键因素，可能为确定治疗靶点和指导治疗策略提供途径。