Chen Shu-Rong, Chang Yang-Chen, Chen Yi, Chen Yih-Fung, Lin Yu-Chi, Chiu Cheng-Chau, Cheng Yuan-Bin
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
J Org Chem. 2025 Apr 11;90(14):5019-5035. doi: 10.1021/acs.joc.5c00280. Epub 2025 Apr 2.
Two novel alkaloids, zoanides A and B ( and ), 12 new zoanthamine-type alkaloids (-), together with two known compounds ( and ) were obtained from the zoantharian . Their structures and absolute configurations were established by extensive spectroscopic data, DP4+ probability calculation, and X-ray crystallographic analyses. Structurally, compound represents an unusual functionalized skeleton caused by oxidative cleavage; compound possesses an unprecedented 6/6/5/6/7-fused pentacyclic carbon skeleton. Additionally, the plausible biosynthetic pathways of and were proposed. All isolates were evaluated in vitro for neuroprotection. Among them, compounds , , , , and exhibited neuroprotection against paclitaxel-induced neurite damage without interfering with the anticancer effects of paclitaxel. Moreover, compounds and demonstrated moderate protective effects against oxaliplatin-induced oxidative stress overload without interfering with the anticancer effects of oxaliplatin.
从珊瑚中获得了两种新型生物碱zoanides A和B（以及）、12种新的海葵胺型生物碱（-），以及两种已知化合物（和）。通过广泛的光谱数据、DP4 +概率计算和X射线晶体学分析确定了它们的结构和绝对构型。在结构上，化合物代表由氧化裂解引起的不寻常官能化骨架；化合物具有前所未有的6/6/5/6/7稠合五环碳骨架。此外，还提出了和可能的生物合成途径。对所有分离物进行了体外神经保护评估。其中，化合物、、、、和对紫杉醇诱导的神经突损伤具有神经保护作用，且不干扰紫杉醇的抗癌作用。此外，化合物和对奥沙利铂诱导的氧化应激过载表现出适度的保护作用，且不干扰奥沙利铂的抗癌作用。
