Wu Xinghan, Xu Wenxin, Huang Xuantao, Dan Nianhua, Chen Yining, Li Zhengjun, Wang Yunbing
College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China.
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.
Biomacromolecules. 2025 Apr 14;26(4):2487-2499. doi: 10.1021/acs.biomac.4c01847. Epub 2025 Apr 2.
Emergency repair of complicated full-thickness abdominal wall defects remains one of the most common and challenging surgical emergencies globally. Here, an integrated polydopamine permeating-cross-linking strategy was innovatively proposed to convert porcine acellular dermal matrix (pADM) into versatile, degradation-resistant biopatches (PDA-pADM) for efficiently repairing full-thickness abdominal wall defects. The strategy significantly addresses the challenge that natural-property improvement and biocompatibility of biomaterials are difficult to balance. Molecularly, dopamine (DA) molecules could fully permeate into the collagen fibers of the acellular dermal matrix and then automatically trigger the interfacial in situ polymerization of dopamine monomers among collagen fibers to achieve the efficient cross-linking of pADM. Surprisingly, the enzymatic durability of the biopatch shows significant improvements, extending the original duration from 3 to 20 d. Comprehensive in vivo experiments have shown that PDA-pADM can effectively promote angiogenesis and inhibit inflammatory response, so as to achieve regeneration and repair of abdominal wall damage.
复杂全层腹壁缺损的急诊修复仍然是全球最常见且最具挑战性的外科急症之一。在此，创新性地提出了一种集成的聚多巴胺渗透交联策略，将猪脱细胞真皮基质（pADM）转化为多功能、抗降解的生物补片（PDA-pADM），用于高效修复全层腹壁缺损。该策略显著解决了生物材料天然性能改善与生物相容性难以平衡的挑战。从分子层面来看，多巴胺（DA）分子能够充分渗透到脱细胞真皮基质的胶原纤维中，然后自动引发胶原纤维间多巴胺单体的界面原位聚合，以实现pADM的高效交联。令人惊讶的是，生物补片的酶耐久性有显著提高，将原来的持续时间从3天延长至20天。全面的体内实验表明，PDA-pADM能够有效促进血管生成并抑制炎症反应，从而实现腹壁损伤的再生和修复。
