癸酸诺龙超生理剂量对大鼠睾丸的即时和远期影响。
Immediate and late effects of supraphysiological doses of nandrolone decanoate on the testis of rats.
作者信息
Felix-Patricio Bruno, Marchon Roger Gaspar, Gregório Bianca Martins, De Souza Diogo Benchimol
机构信息
Universidade Federal Fluminense - Department of Natural Sciences - Rio das Ostras (RJ) - Brazil.
Universidade do Estado do Rio de Janeiro - Urogenital Research Unit - Rio de Janeiro (RJ) - Brazil.
出版信息
Acta Cir Bras. 2025 Mar 31;40:e402925. doi: 10.1590/acb402925. eCollection 2025.
PURPOSE
To investigate the effects of supraphysiologic doses of nandrolone decanoate on the testicular morphology of rats and if these effects could be transitory or permanent.
METHODS
Twenty-five male rats were divided in four groups. C28 and C40 were control rats killed with 28 and 40 weeks old, respectively; and T28 and T40 were treated with nandrolone decanoate (10 mg/kg) and killed immediately after the treatment (T28) or 12 weeks after the end of treatment (T40). The testis weight and volume were measured, and the seminiferous tubule area and epithelium height were assessed by histomorphometric methods.
RESULTS
The seminiferous tubules area and epithelium height of group T28 were reduced in comparison to C28. Group T40 showed reduced testicular weight and volume, as well as seminiferous tubule area and epithelium height in comparison to C40.
CONCLUSION
The use of nandrolone decanoate promotes major structural modifications on the testes of rats. These modifications are even worse 12 weeks after ending the use of the anabolic androgenic steroid.
目的
研究超生理剂量的癸酸诺龙对大鼠睾丸形态的影响，以及这些影响是暂时的还是永久的。
方法
将25只雄性大鼠分为四组。C28和C40为分别在28周龄和40周龄时处死的对照大鼠；T28和T40用癸酸诺龙（10mg/kg）治疗，并在治疗后立即处死（T28）或在治疗结束后12周处死（T40）。测量睾丸重量和体积，并用组织形态计量学方法评估生精小管面积和上皮高度。
结果
与C28相比，T28组的生精小管面积和上皮高度降低。与C40相比，T40组的睾丸重量和体积降低，生精小管面积和上皮高度也降低。
结论
使用癸酸诺龙会对大鼠睾丸造成主要的结构改变。在停止使用合成代谢雄激素类固醇12周后，这些改变会更严重。
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