Noorafshan Ali, Karbalay-Doust Saied, Ardekani Fakhrodin Mesbah
Shiraz University of Medical Sciences, Shiraz, Iran.
APMIS. 2005 Feb;113(2):122-5. doi: 10.1111/j.1600-0463.2005.apm1130205.x.
Anabolic-androgenic steroid (AAS) compounds rank among the drugs most widely abused with the goal of improving athletic ability, appearance, or muscle mass. It has been shown that these compounds have adverse effects on human and animal physiology and sperm quality, but quantitative structural changes of the testis have received less attention. The present study was conducted to evaluate the effects of nandrolone decanoate, which is one of the AAS compounds, on testis weight and volume, diameter and length of seminiferous tubules in rats by unbiased stereological methods. Adult rats were divided into three groups. The first comprised control rats; the second and third groups received low and high doses of nandrolone decanoate for 14 weeks. The rats were then left untreated for 14 weeks. After removal of the testis, stereological study of these tissues showed that the mean volume of testis and length of the seminiferous tubules in the animals that received high doses of nandrolone decanoate were reduced approximately 32% (p<0.01) and approximately 31% (p<0.04), respectively, in comparison with the control group. It can be concluded that the high doses of nandrolone decanoate produce structural changes in the rat testis that remain 14 weeks after stopping injection of the drug.
合成代谢雄激素类固醇（AAS）化合物是滥用最为广泛的药物之一，其目的是提高运动能力、改善外表或增加肌肉量。研究表明，这些化合物对人和动物的生理机能以及精子质量具有不良影响，但睾丸的定量结构变化却较少受到关注。本研究旨在通过无偏倚体视学方法，评估AAS化合物之一的癸酸诺龙对大鼠睾丸重量和体积、生精小管直径和长度的影响。成年大鼠被分为三组。第一组为对照大鼠；第二组和第三组分别接受低剂量和高剂量的癸酸诺龙，持续14周。之后让大鼠停药14周。摘除睾丸后，对这些组织进行的体视学研究表明，与对照组相比，接受高剂量癸酸诺龙的动物的睾丸平均体积和生精小管长度分别减少了约32%（p<0.01）和约31%（p<0.04）。可以得出结论，高剂量的癸酸诺龙会使大鼠睾丸产生结构变化，且在停药14周后这些变化依然存在。
