一例从波兰输入德国的致命性呼吸道白喉病例：是否与波兰一个未被发现的输入性白喉聚集性病例有关？
A case of fatal respiratory diphtheria imported from Poland to Germany: possible link to an undetected imported diphtheria cluster in Poland?
作者信息
Berger Anja, Zasada Aleksandra A, Dangel Alexandra, Piekarska Katarzyna, Paradowska-Stankiewicz Iwona, Bengs Katja, Noll Christine, Sing Andreas
机构信息
National Consiliary Laboratory for Diphtheria, Oberschleißheim, Germany.
WHO Collaborating Centre for Diphtheria, Oberschleißheim, Germany.
出版信息
Infection. 2025 Apr 2. doi: 10.1007/s15010-025-02522-y.
PURPOSE
Diphtheria is a re-emerging vaccine-preventable disease, mainly caused by toxigenic Corynebacterium diphtheriae.
METHODS
Here, we report a fatal respiratory diphtheria infection in a Polish woman travelling to Germany possibly linked to a cutaneous diphtheria infection in a homeless man living in the same geographic area. Laboratory diagnostics involving MALDI-TOF MS, tox-gene PCR, Lateral Flow Immuno Assay, a modified Elek test and Next Generation Sequencing (NGS) identified the causative strain as cotrimoxazole-resistant toxigenic Corynebacterium diphtheriae biotype mitis, sequence type ST574. Moreover, a review on the diphtheria situation in Poland is presented.
RESULTS
NGS data suggest a common source of infection in Poland and a possible link to the Europe-wide outbreak of imported diphtheria with C. diphtheriae since 2022. This is the first diphtheria case in Poland since 2000.
目的
白喉是一种再度出现的可通过疫苗预防的疾病，主要由产毒白喉棒状杆菌引起。
方法
在此，我们报告一名前往德国的波兰女性发生致命性呼吸道白喉感染，可能与居住在同一地理区域的一名无家可归男性的皮肤白喉感染有关。通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）、毒素基因聚合酶链反应（tox-gene PCR）、侧向流免疫测定、改良埃lek试验和下一代测序（NGS）进行的实验室诊断确定致病菌株为耐复方新诺明的产毒白喉棒状杆菌轻型生物型，序列类型为ST574。此外，还介绍了波兰白喉情况的综述。
结果
NGS数据表明波兰存在共同感染源，并且可能与自2022年以来欧洲范围内由白喉棒状杆菌引起的输入性白喉疫情有关。这是波兰自2000年以来的首例白喉病例。
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