Lee Christine A
University College London, London, UK.
Haemophilia. 2025 Jul;31(4):601-606. doi: 10.1111/hae.70043. Epub 2025 Apr 2.
The UK Infected Blood Inquiry (IBI) considered the transfusion transmitted infections hepatitis B and C, HIV, and vCJD. The inquiry lasted 6 years during 2018 to 2024 and reported to the UK parliament on 20 May, 2024. It concluded that at least 3000 people died because of the recklessness and obstinacy of officialdom and it has been reported that victims may be compensated an estimated £12 bn-£14 bn ($16 bn-$18 bn). This personal reflection considers people with the bleeding disorder haemophilia, who were infected with blood products. The longevity of both the understanding of the infections, as well as the long natural history of the infections themselves, is set in the context of the medicine practiced by physicians with whom the author was taught and practiced over a period of 40 years. These physicians used blood products to advance the care and life expectancy of patients whilst the ill understood and unforeseen side effects of treatment were slowly elucidated: their contributions were severely criticised but their evidence could not be presented through ill health or death. It is recommended that 'no-fault compensation' schemes should be provided, especially in the era of new and sometimes irreversible therapies, and evidence-based medicine is protected.
英国感染血液调查委员会(IBI)对输血传播感染疾病进行了调查,包括乙型和丙型肝炎、艾滋病病毒(HIV)以及变异型克雅氏病(vCJD)。该调查历时6年,从2018年持续至2024年,并于2024年5月20日向英国议会提交报告。调查得出结论,至少3000人因官僚作风的鲁莽和固执而死亡,据报道,受害者可能会获得约120亿至140亿英镑(160亿至180亿美元)的赔偿。这篇个人反思文章关注的是患有出血性疾病血友病且因血液制品感染疾病的人群。对这些感染疾病的认知历程以及感染本身漫长的自然病程,是在作者接受教导并从业40年期间所接触的医生所践行的医学背景下展开的。这些医生使用血液制品来改善患者的治疗和预期寿命,与此同时,治疗中那些难以理解且无法预见的副作用也在逐渐被揭示出来:他们的贡献受到了严厉批评,但他们的证据却无法通过健康状况不佳或死亡来呈现。建议设立“无过错赔偿”计划,尤其是在新的、有时甚至是不可逆的治疗方法出现的时代,同时要保障循证医学的发展。