Pasquier C, Laoussadi S, Sarfati G, Raichvarg D, Amor B
Clin Exp Rheumatol. 1985 Apr-Jun;3(2):123-6.
The activity of cyanide-sensitive and cyanide-insensitive superoxide dismutase (CNs- and CNi-SOD) was measured in polymorphonuclear neutrophils isolated from the blood of patients with ankylosing spondylitis (A.S.) or adults with rheumatoid arthritis (R.A.). Our purpose was to detect alterations in the protecting activity of these enzymes that might cause rheumatic lesions secondary to superoxide anion generation in the inflammatory loci. There was no difference in total SOD activity (CNs + CNi) in either A.S. or R.A. when compared to the control group. In contrast, CNi-SOD activity decreased in R.A. and A.S. and CNs-SOD activity rose significantly in A.S. only. None of the changes observed in SOD activity correlated with patient's age, erythrocyte sedimentation rate, clinical evolution of the disease or the drug doses administered. It is concluded that the reduced activity of CNi-SOD might be partly responsible for the reduced protection of the joints against oxygen-free radicals in patients with A.S. or R.A. Other factors however appear to have greater effects on the clinical evolution of these diseases.
在从强直性脊柱炎（A.S.）患者或类风湿性关节炎（R.A.）成年患者血液中分离出的多形核中性粒细胞中，测定了对氰化物敏感和不敏感的超氧化物歧化酶（CNs - SOD和CNi - SOD）的活性。我们的目的是检测这些酶的保护活性的改变，这些改变可能会导致炎症部位超氧阴离子生成继发的风湿性病变。与对照组相比，A.S.或R.A.患者的总超氧化物歧化酶活性（CNs + CNi）均无差异。相反，R.A.和A.S.患者的CNi - SOD活性降低，仅A.S.患者的CNs - SOD活性显著升高。超氧化物歧化酶活性的任何变化均与患者年龄、红细胞沉降率、疾病的临床进展或所服用药物剂量无关。得出的结论是，CNi - SOD活性降低可能部分导致了A.S.或R.A.患者关节对氧自由基的保护作用减弱。然而，其他因素似乎对这些疾病的临床进展有更大影响。
