Heizer W D, Orringer E P
Gastroenterology. 1977 Mar;72(3):527-32.
On March 26, 1970, a 33-year-old male suffered intestinal infarction which required total enterectomy and duodeno-transverse colostomy. Nutrition was maintained in the hospital by daily parenteral feeding for 2 months postoperatively, after which parenteral feedings were decreased and stopped for long periods. Various oral dietary regimens failed to provide adequate nutrition, and the patient lost 40 kg and became severely malnourished during the next 13 months. In June 1971, supplemental home parenteral nutrition (PN) via an arteriovenous fistula was instituted on a 3 or 4 nights per week basis. The patient's weight and strength increased markedly after institution of the home supplemental PN program. The first fistula became occluded after 9.5 months of home PN use and subsequent successive fistulae have remained patent for 31.3, 8.8, and 5.5 months of use. The patient prepares his own PN fluids at home, using a commercial device for filling plastic intravenous fluid bags. Although several different types of fluid have been used, the current mixture of 25% glucose and 2.75% amino acids with added vitamins, potassium, calcium, magnesium, and insulin plus simultaneously administered lipid emulsion has proven most effective. Only when the patient's low fat, low oxalate diet is supplemented with this parenteral mixture 4 nights each week is he in positive nitrogen, phosphorus, and magnesium balance. However, his negative calcium balance is only partially corrected. There has been no sepsis, embolism, or fistula infection during 5 years of home PN.
1970年3月26日,一名33岁男性发生肠梗死,需行全小肠切除术及十二指肠-横结肠造口术。术后2个月在医院通过每日肠外营养维持营养,之后肠外营养逐渐减少并长期停用。各种口服饮食方案均未能提供足够营养,在接下来的13个月里,患者体重减轻40公斤,严重营养不良。1971年6月,通过动静脉内瘘开始每周3至4晚进行家庭补充肠外营养(PN)。实施家庭补充PN方案后,患者体重和体力明显增加。第一个内瘘在家庭PN使用9.5个月后闭塞,随后的连续内瘘分别使用了31.3、8.8和5.5个月仍保持通畅。患者在家中使用商业设备自行配制PN液,用于填充塑料静脉输液袋。虽然使用了几种不同类型的液体,但目前25%葡萄糖和2.75%氨基酸加维生素、钾、钙、镁、胰岛素并同时给予脂肪乳剂的混合液已被证明最有效。只有当患者的低脂、低草酸饮食每周4晚补充这种肠外混合液时,他才处于正氮、磷和镁平衡状态。然而,他的负钙平衡仅得到部分纠正。在家庭PN的5年中未发生败血症、栓塞或内瘘感染。