Daniel Morgan, McInnes-Dean Hannah, Wu Wing Han, Fisher Jane, Lafarge Caroline, Leeson-Beevers Kerry, Lewis Celine, Peet Sophie, Tapon Dagmar, Wynn Sarah L, Chitty Lyn S, Hill Melissa, Peter Michelle
North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.
Prenat Diagn. 2025 Apr 2. doi: 10.1002/pd.6792.
To develop and evaluate an animation for parents about prenatal sequencing.
A total of 428 participants who had been pregnant, or whose partner had been pregnant, in the past 24 months. Parents, patient organisation representatives and clinicians co-designed the animation describing prenatal sequencing (pS). Participants were semi-randomly assigned to receive one of three interventions (leaflet, animation or both) and answered questions assessing their self-perceived and objective knowledge before (T1) and after the intervention (T2). Satisfaction with and ease of understanding of the information was assessed at T2.
Survey respondents' (leaflet [n = 130], animation [n = 153] and both leaflet and animation [n = 145]) self-perceived understanding and knowledge of genetics and objective knowledge of pS increased after all interventions. The leaflet and animation were equally effective in improving the objective knowledge of pS (F(2, 421) = 2.48, p = 0.085). The animation was viewed positively. Preferences for information format were mixed.
Animated and written information can improve knowledge and understanding of pS. Our animation expands the available information resources for parents offered pS. Further research should evaluate the utility of the animation in a clinical setting.
为家长制作并评估一部关于产前测序的动画。
共有428名在过去24个月内怀孕或其伴侣怀孕的参与者。家长、患者组织代表和临床医生共同设计了描述产前测序(pS)的动画。参与者被半随机分配接受三种干预措施之一(传单、动画或两者皆有),并在干预前(T1)和干预后(T2)回答评估其自我认知和客观知识的问题。在T2时评估对信息的满意度和理解的难易程度。
所有干预措施后,调查受访者(传单组[n = 130]、动画组[n = 153]以及传单和动画组[n = 145])对遗传学的自我认知理解和知识以及pS的客观知识均有所增加。传单和动画在提高pS的客观知识方面同样有效(F(2, 421) = 2.48,p = 0.085)。动画受到了积极评价。对信息格式的偏好各不相同。
动画和书面信息可以提高对pS的知识和理解。我们的动画扩展了为接受pS的家长提供的可用信息资源。进一步的研究应评估该动画在临床环境中的效用。