Rystedt I
Contact Dermatitis. 1985 Apr;12(4):185-91. doi: 10.1111/j.1600-0536.1985.tb01103.x.
A series of 955 persons aged 24-44 years, with atopic dermatitis in childhood, were interviewed in order to identify factors which increase the risk of developing hand eczema in adult life, or aggravate already existing hand eczema. Endogenous (constitutional) factors were in general of greater importance than exogenous factors, viz. chemicals, water, soil and wear (friction). Eczematous involvement of the hands in childhood was of predominant importance. In individuals without such involvement, severe (widespread) dermatitis in childhood was a dominant factor. Other factors, each of them significantly more important than the exogenous ones, were persistent eczema on other parts of the body and dry/itchy skin. The factors female sex, family history of atopic dermatitis and simultaneous bronchial asthma/allergic rhinitis were associated with increased risk of developing hand eczema in adult life, but were of limited importance compared with the other endogenous and the exogenous factors.
为了确定增加成年后患手部湿疹风险或加重已存在的手部湿疹的因素，对955名年龄在24至44岁之间、童年时期患有特应性皮炎的人进行了访谈。一般来说，内源性（体质性）因素比外源性因素更重要，即化学物质、水、土壤和磨损（摩擦）。童年时期手部湿疹的累及最为重要。在没有这种累及的个体中，童年时期严重（广泛）的皮炎是一个主要因素。其他因素，每一个都比外源性因素重要得多，是身体其他部位的持续性湿疹和皮肤干燥/瘙痒。女性性别、特应性皮炎家族史以及同时患有支气管哮喘/过敏性鼻炎与成年后患手部湿疹的风险增加有关，但与其他内源性和外源性因素相比，其重要性有限。
