Itorralba Justine, Brand-Arzamendi Koroboshka, Saab Georges, Muccilli Alexandra, Schneider Raphael
Department of Medicine, St. Michael's Hospital, Unity Health Toronto, 30 Bond St, 17th floor, Peter Gilgan Tower, Toronto, ON, M5B 1W8, Canada.
Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
BMC Neurol. 2025 Apr 2;25(1):136. doi: 10.1186/s12883-025-04145-0.
MS is characterized by persistent central nervous system (CNS) inflammation. Investigating the CNS-compartmentalized inflammation associated with progressive MS could uncover new biomarkers and therapeutic targets. Cerebrospinal fluid (CSF) interleukin-6 (IL-6) can be markedly elevated in neuroinflammatory conditions, such as neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease. This study investigated the association between CSF IL-6 levels, progressive disease, and disease severity in MS.
Advanced technologies, including single-molecule arrays and microfluidics, were used to analyse CSF samples from individuals with MS at the time of diagnosis for IL-6. IL-6 levels were then correlated with clinical course, disease severity, and other known biomarkers associated with inflammation and disease severity.
Elevated IL-6 levels in the CSF were found in individuals with progressive MS, and CSF IL-6 showed positive correlations with the Expanded Disability Status Scale, the Multiple Sclerosis Severity Score, and CSF glial fibrillary acidic protein levels.
IL-6 in CSF indicates ongoing CNS inflammation and may contribute to the compartmentalized inflammation associated with disease progression and overall disease severity.
多发性硬化症（MS）的特征是中枢神经系统（CNS）持续存在炎症。研究与进展型MS相关的CNS分区炎症可能会发现新的生物标志物和治疗靶点。在神经炎性疾病，如视神经脊髓炎谱系障碍和髓鞘少突胶质细胞糖蛋白抗体相关疾病中，脑脊液（CSF）白细胞介素-6（IL-6）可显著升高。本研究调查了MS患者CSF中IL-6水平、疾病进展与疾病严重程度之间的关联。
采用包括单分子阵列和微流控技术在内的先进技术，对MS患者诊断时的CSF样本进行IL-6分析。然后将IL-6水平与临床病程、疾病严重程度以及其他与炎症和疾病严重程度相关的已知生物标志物进行关联分析。
进展型MS患者的CSF中IL-6水平升高，且CSF中IL-6与扩展残疾状态量表、多发性硬化症严重程度评分以及CSF胶质纤维酸性蛋白水平呈正相关。
CSF中的IL-6表明CNS存在持续炎症，可能与疾病进展和整体疾病严重程度相关的分区炎症有关。
