O'Day D M
Curr Eye Res. 1985 Mar;4(3):243-52. doi: 10.3109/02713688509000856.
The study of experimental fungal infections requires effective animal models. Two such models in the rabbit model have been developed and applied to various aspects of topical antifungal therapy. In these models, the polyenes, as a class, are superior in efficacy to the imidazoles and flucytosine, but efficacy is clearly strain related. Corticosteroids, when administered concomitantly with antifungal agents, adversely influence antifungal activity in vivo. This steroid effect is inversely proportional to the efficacy of the antifungal agent. The corneal epithelium appears to be a significant barrier to the penetration of the polyene antibiotics. Although the predictive power of in vitro susceptibility testing as a guide to in vivo efficacy is uncertain, a correlation was seen between the in vivo and in vitro effect for amphotericin B against three strains of Candida albicans.
实验性真菌感染的研究需要有效的动物模型。已经开发出两种兔模型并将其应用于局部抗真菌治疗的各个方面。在这些模型中，作为一类药物的多烯类在疗效上优于咪唑类和氟胞嘧啶，但疗效明显与菌株相关。当与抗真菌剂同时给药时，皮质类固醇会对体内抗真菌活性产生不利影响。这种类固醇效应与抗真菌剂的疗效成反比。角膜上皮似乎是多烯类抗生素渗透的重要屏障。尽管体外药敏试验作为体内疗效指导的预测能力尚不确定，但两性霉素B对三株白色念珠菌的体内和体外效应之间存在相关性。
