Liu Xin, Gao Yahan, Yang Fan, Qian Min, You Shuhui, Wang Xiaoxiao, Qin Fenju, Xiang Min, Guo Weiqiang
School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, China.
School of Pharmacy, Suzhou Vocational Health College, Suzhou, China.
Anticancer Agents Med Chem. 2025;25(16):1188-1197. doi: 10.2174/0118715206372305250319064431.
Cancer, with a high incidence and mortality rate, has emerged as a major public health problem worldwide. Currently, new approaches, such as targeted therapy and immunotherapy, are giving hope to patients. However, drug resistance and adverse side effects are major barriers to cancer treatment. As a result, there is a greater focus on the development of cancer therapy strategies and medications with low toxicity and high efficacy. Cryptotanshinone (CTS), a diterpenoid quinone extracted from , exhibits a wide range of biological activities, including immunomodulatory, anti-inflammatory, and antitumor effects. In recent years, numerous studies have highlighted its significant antitumor properties, indicating potential clinical applications and development value. However, the clinical use of cryptotanshinone has been limited due to its poor water solubility and low bioavailability. To overcome these limitations, researchers are exploring new drug delivery systems, and novel formulation systems based on nanotechnology are being developed to improve the delivery and effectiveness of cryptotanshinone. In this review, we aim to consolidate the existing knowledge regarding the antitumor effects of cryptotanshinone and emphasize the latest advancements in its nanoformulation development. We hope to provide insights that will further improve the antitumor efficacy and clinical applicability of cryptotanshinone.
癌症的发病率和死亡率都很高，已成为全球主要的公共卫生问题。目前，靶向治疗和免疫治疗等新方法给患者带来了希望。然而，耐药性和副作用是癌症治疗的主要障碍。因此，人们更加关注开发低毒高效的癌症治疗策略和药物。隐丹参酮（CTS）是从[植物名称缺失]中提取的一种二萜醌，具有广泛的生物活性，包括免疫调节、抗炎和抗肿瘤作用。近年来，大量研究突出了其显著的抗肿瘤特性，显示出潜在的临床应用和开发价值。然而，由于隐丹参酮水溶性差、生物利用度低，其临床应用受到限制。为克服这些限制，研究人员正在探索新的药物递送系统，基于纳米技术的新型制剂系统正在被开发，以提高隐丹参酮的递送效率和效果。在本综述中，我们旨在整合关于隐丹参酮抗肿瘤作用的现有知识，并强调其纳米制剂开发的最新进展。我们希望提供相关见解，以进一步提高隐丹参酮的抗肿瘤疗效和临床适用性。
