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甲状旁腺功能亢进-颌骨肿瘤综合征:1例罕见病例报告及文献复习

Hyperparathyroidism-Jaw Tumor Syndrome: A Rare Case Report and Literature Review.

作者信息

Memon Maria, Ibrahim Nouman, Khan Muhammad Momin, Khatri Aakash Rai, Meghwar Mahesh Kumar, Siddiqui Farina Fatima, Rajput Maisam Ali, Jlailati Alaa

机构信息

Department of General Surgery Liaquat University Hospital Hyderabad Pakistan.

Department of Internal Medicine Liaquat University Hospital Hyderabad Pakistan.

出版信息

Clin Case Rep. 2025 Apr 1;13(4):e70390. doi: 10.1002/ccr3.70390. eCollection 2025 Apr.

Abstract

Prompt identification of Hyperparathyroidism-Jaw Tumor Syndrome (HPT-JT) is vital, particularly for those with a family history or unusual symptoms like progressive facial changes. By employing a thorough diagnostic strategy that includes biochemical tests, imaging, and genetic analysis, we can achieve early diagnosis and effective intervention. In this case, the patient displayed maxillofacial tumors, hypercalcemia, and increased parathyroid hormone levels. Imaging confirmed a parathyroid adenoma, while histopathology showed characteristics of brown tumors. Subtotal parathyroidectomy is the recommended treatment. Additionally, regular follow-ups every 6 months involving biochemical tests and imaging are crucial for ensuring the best patient outcomes.

摘要

甲状旁腺功能亢进-颌骨肿瘤综合征(HPT-JT)的早期识别至关重要,特别是对于那些有家族病史或出现如进行性面部改变等异常症状的患者。通过采用包括生化检测、影像学检查和基因分析在内的全面诊断策略,我们可以实现早期诊断和有效干预。在这个病例中,患者表现出颌面部肿瘤、高钙血症和甲状旁腺激素水平升高。影像学检查证实为甲状旁腺腺瘤,而组织病理学显示为棕色肿瘤的特征。建议进行甲状旁腺次全切除术。此外,每6个月定期进行生化检测和影像学检查的随访对于确保患者获得最佳治疗效果至关重要。

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