Sumana Mahadevaiah Neelambike, Rao Morubagal Raghavendra, Chitharagi Vidyavathi B, Satyasai Badveti, Shettar Supreeta R, Swamy Veerabhadra G S, Eshwarappa Chinchana S, Maheshwarappa Yogeesh D
Department of Microbiology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, India.
Front Med (Lausanne). 2025 Mar 19;12:1513974. doi: 10.3389/fmed.2025.1513974. eCollection 2025.
serovar Weltevreden, a non-typhoidal serovar, has emerged as a significant foodborne pathogen, particularly in Southeast Asian countries. While it is commonly associated with gastroenteritis and foodborne outbreaks, it can also lead to invasive infections in immunocompromised adults and neonates. This case report presents a rare instance of myocarditis associated with Weltevreden gastroenteritis in a 43-year-old healthy male physician from South India. The patient had a month-long history of intermittent fever, which worsened 2 days before admission, along with myalgia and headache. A day after the admission the patient developed diarrhea. Upon investigation, stool culture revealed serovar Weltevreden. Notably, the patient had a genetic predisposition to inflammatory bowel disease and reported recent use of nonsteroidal anti-inflammatory drugs, which may have increased his susceptibility to non-typhoidal infection. The patient also developed myocarditis, making this the first reported case of Weltevreden-associated myocarditis in the region. Antimicrobial susceptibility testing indicated ciprofloxacin susceptibility, an increasingly rare finding, as most reported serovar Weltevreden cases exhibit ciprofloxacin resistance. The patient recovered following treatment with ciprofloxacin and was discharged with instructions for follow-up. This case highlights the need for heightened awareness of the potential for non-typhoidal infections to cause systemic manifestations, even in individuals without major underlying comorbidities. Continuous monitoring of antimicrobial resistance patterns and strict food safety measures are essential to control outbreaks of these emerging pathogens.
韦尔泰弗里登血清型，一种非伤寒血清型，已成为一种重要的食源性病原体，尤其是在东南亚国家。虽然它通常与肠胃炎和食源性疾病暴发有关，但它也可导致免疫功能低下的成年人和新生儿发生侵袭性感染。本病例报告介绍了一名来自印度南部的43岁健康男性医生罕见的与韦尔泰弗里登肠胃炎相关的心肌炎病例。患者有长达一个月的间歇性发热病史，入院前2天病情加重，伴有肌痛和头痛。入院一天后患者出现腹泻。经调查，粪便培养显示为韦尔泰弗里登血清型。值得注意的是，该患者有炎性肠病的遗传易感性，并报告近期使用过非甾体抗炎药，这可能增加了他对非伤寒感染的易感性。患者还发生了心肌炎，这是该地区首例报告的与韦尔泰弗里登相关的心肌炎病例。抗菌药敏试验表明对环丙沙星敏感，这一发现越来越罕见，因为大多数报告的韦尔泰弗里登血清型病例都表现出对环丙沙星耐药。患者经环丙沙星治疗后康复并出院，并得到随访指示。该病例强调，即使在没有主要潜在合并症的个体中，也需要提高对非伤寒感染导致全身表现可能性的认识。持续监测抗菌耐药模式和严格的食品安全措施对于控制这些新出现病原体的暴发至关重要。
