Kaufman P L, Bárány E H
Invest Ophthalmol Vis Sci. 1977 Jan;16(1):47-53.
In cynomolgus monkeys, intracameral infusion of 0.2 to 5.0 mug of cytochalasin B caused an increase in outflow facility, as measured by two-level constant pressure perfusion. Cytochalasin B had its full effect in eyes which had undergone surgical disinsertion of the ciliary muscle from the scleral spur, and were therefore insensitive to pilocarpine. The cytochalasin effect was apparent in less than 20 min. and was largely reversible over a few hours. Thirty to 50 days after the infusion, facility was normal, and a second reaction could be elicited. No early or late damage to anterior segment structures was apparent by routine biomicroscopy during or after the single administration.
在食蟹猴中，通过两级恒压灌注测量，前房内注入0.2至5.0微克的细胞松弛素B会导致房水流畅度增加。细胞松弛素B在睫状肌已从巩膜突手术离断、因此对毛果芸香碱不敏感的眼中具有完全效应。细胞松弛素的效应在不到20分钟内就很明显，并且在数小时内基本可逆。注入后30至50天，房水流畅度正常，并且可以引发第二次反应。单次给药期间或之后，通过常规生物显微镜检查未发现眼前节结构有早期或晚期损伤。
