Kaufman P L, Erickson K A, Bárány E H
Invest Ophthalmol Vis Sci. 1983 Feb;24(2):159-64.
Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber in surgically virgin, aniridic, and ciliary muscle disinserted cynomolgus monkey eyes 6 to 13 times at 1- to 2-month intervals over periods of 8 to 24 months. Facility decreased approximately 15 to 20% between consecutive thirds of the perfusion history, independent of eye type. The facility decreases were too large to be explained by decreased uveoscleral facility or pseudofacility, and were not mediated by the iris, ciliary muscle, or gonioscopically or ultrastructurally apparent chamber angle alterations. They most probably reflected functional alterations in the trabecular meshwork/inner wall of Schlemm's canal. Intraocular pressure as measured by applanation tonometry did not increase progressively, most probably due to a decreased rate of aqueous humor formation.
通过对手术未处理、无虹膜和睫状肌离断的食蟹猴眼进行前房两级恒压灌注来测定总流出率，在8至24个月的时间内，每隔1至2个月进行6至13次测量。在灌注过程的连续三分之一阶段之间，流出率下降了约15%至20%，与眼的类型无关。流出率的下降幅度太大，无法用葡萄膜巩膜流出率或假性流出率的降低来解释，也不是由虹膜、睫状肌或前房角在房角镜或超微结构上明显的改变介导的。它们很可能反映了小梁网/施莱姆管内壁的功能改变。通过压平眼压计测量的眼压并未逐渐升高，很可能是由于房水生成速率降低。
