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RAB39B：一种通过多组学和功能验证确定的急性髓系白血病新型生物标志物。

RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation.

作者信息

Chen Shuo, Li Mengxing, Wang Jishi

机构信息

Department of Hematology, Affiliated Medicine of Guizhou Medical University, Guiyang, 550001, China.

Graduate School, Guizhou Medical University, Guiyang, 550001, China.

出版信息

Open Med (Wars). 2025 Mar 28;20(1):20251168. doi: 10.1515/med-2025-1168. eCollection 2025.

DOI:10.1515/med-2025-1168
PMID:40177653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11964188/
Abstract

BACKGROUND

The objective of this research was to investigate the involvement of RAB39B in acute myeloid leukemia (AML) using bioinformatics analysis and experiments for validation.

METHODS

In this article, RNA sequencing data from The Cancer Genome Atlas and genotype-tissue expression were utilized to analyze the expression of RAB39BA and identify differentially expressed genes.

RESULTS

AML exhibited elevated expression of RAB39B in diverse tumor types. In laboratory experiments, it has been demonstrated that RAB39B exhibits a significant expression level in AML cell lines when compared to normal peripheral blood monocytes. Moreover, RAB39B is closely linked to the growth and programmed cell death of AML cells.

CONCLUSION

In conclusion, RAB39B shows potential as a biomarker for the identification and prediction of AML, contributing to the growth and cell death processes in AML.

摘要

背景

本研究的目的是通过生物信息学分析和实验验证来研究RAB39B在急性髓系白血病（AML）中的作用。

方法

在本文中，利用来自癌症基因组图谱的RNA测序数据和基因型-组织表达来分析RAB39BA的表达并鉴定差异表达基因。

结果

AML在多种肿瘤类型中表现出RAB39B表达升高。在实验室实验中，已证明与正常外周血单核细胞相比，RAB39B在AML细胞系中表现出显著的表达水平。此外，RAB39B与AML细胞的生长和程序性细胞死亡密切相关。

结论

总之，RAB39B显示出作为AML识别和预测生物标志物的潜力，有助于AML的生长和细胞死亡过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/4d214f685052/j_med-2025-1168-fig010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/e2663491364b/j_med-2025-1168-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/8dd7df79cead/j_med-2025-1168-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/30d1d9b654b2/j_med-2025-1168-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/6d18a1e97dbe/j_med-2025-1168-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/238f3fc39857/j_med-2025-1168-fig005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/c907fa073c0e/j_med-2025-1168-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/9273c43b15d4/j_med-2025-1168-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/365ae25db35a/j_med-2025-1168-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/5910eb8a12d7/j_med-2025-1168-fig009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/4d214f685052/j_med-2025-1168-fig010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/e2663491364b/j_med-2025-1168-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/8dd7df79cead/j_med-2025-1168-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/30d1d9b654b2/j_med-2025-1168-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/6d18a1e97dbe/j_med-2025-1168-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/238f3fc39857/j_med-2025-1168-fig005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/c907fa073c0e/j_med-2025-1168-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/9273c43b15d4/j_med-2025-1168-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/365ae25db35a/j_med-2025-1168-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/5910eb8a12d7/j_med-2025-1168-fig009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e182/11964188/4d214f685052/j_med-2025-1168-fig010.jpg

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本文引用的文献

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Biomedicines. 2024 Dec 23;12(12):2921. doi: 10.3390/biomedicines12122921.
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Detection of Partial Tandem Duplication by Optical Genome Mapping in Myeloid Neoplasms: Associated Cytogenetics, Gene Mutations, Treatment Responses, and Patient Outcomes.通过光学基因组图谱检测髓系肿瘤中的部分串联重复：相关细胞遗传学、基因突变、治疗反应及患者预后
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老年急性髓系白血病患者的临床特征与结局：一项真实世界研究
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Acute myeloid leukemia associated RUNX1 variants induce aberrant expression of transcription factor TCF4.急性髓系白血病相关的RUNX1变体诱导转录因子TCF4的异常表达。
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The Validation of Digital PCR-Based Minimal Residual Disease Detection for the Common Mutations in IDH1 and IDH2 Genes in Patients with Acute Myeloid Leukemia.基于数字PCR的急性髓系白血病患者IDH1和IDH2基因常见突变微小残留病检测的验证
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