Rivory Phoebe, Lee Rogan, Ward Michael P, Šlapeta Jan
Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia.
New South Wales Health Pathology, Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3 Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Westmead, New South Wales, Australia.
J Infect Dis. 2025 Jul 30;232(1):e150-e158. doi: 10.1093/infdis/jiaf173.
Neural angiostrongyliasis (NA), caused by rat lungworm (Angiostrongylus cantonensis), is an emerging zoonotic disease on Australia's east coast. The number of cases has risen since 2010. This study investigated the diagnosis, genetic diversity of A cantonensis, and spatial and temporal dynamics of canine NA (CNA). We analyzed cerebrospinal fluid samples from 180 clinically suspected cases (2020-2024) using AcanR3990 quantitative polymerase chain reaction, confirming infection in 93. Cases were detected around Brisbane and Sydney, with peak occurrence in 2022 (32 cases). Generalized linear modeling demonstrated that CNA occurrence depends on immediate and long-term rainfall (1- and 10- to 12-month lags) and medium-term temperature changes (5- to 7-month lags). Partial cox1 sequencing revealed Ac13 as the dominant haplotype (9/15). Comparison with an established enzyme-linked immunosorbent assay using 50 randomly selected samples showed substantial agreement (κ = 0.66). With many cases likely remaining undiagnosed, NA poses an ongoing One Health issue in Australia.
神经血管圆线虫病（NA）由广州管圆线虫（Angiostrongylus cantonensis）引起，是澳大利亚东海岸一种新出现的人畜共患病。自2010年以来病例数有所上升。本研究调查了犬类NA（CNA）的诊断、广州管圆线虫的遗传多样性以及时空动态。我们使用AcanR3990定量聚合酶链反应分析了180例临床疑似病例（2020 - 2024年）的脑脊液样本，确诊93例感染。病例在布里斯班和悉尼周边被检测到，2022年出现病例高峰（32例）。广义线性模型表明，CNA的发生取决于近期和长期降雨（滞后1个月以及10至12个月）以及中期温度变化（滞后5至7个月）。部分cox1测序显示Ac13是主要单倍型（9/15）。使用50个随机选择的样本与既定的酶联免疫吸附测定法进行比较，显示出高度一致性（κ = 0.66）。由于许多病例可能仍未被诊断出来，NA在澳大利亚仍然是一个持续存在的“同一健康”问题。
